ECE2023 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (159 abstracts)
Sex-driven factors associated with anxiety and depression in Type 1 Diabetes Mellitus (T1DM) and Latent Autoimmune Diabetes in Adults (LADA)
Enrico Saudelli 1,2 , Simona Moscatiello 1 , Michele Baldari 1,2 , Claudio Bongiorno 1,2 , Stefano Zucchini 3 , Giulio Maltoni 3 , Alessandro Agostini 4 , Danilo Ribichini 1 , Alessia Bruco 1,2 , Valentina Lo Preiato 1 , Gilberto Laffi 1 , Uberto Pagotto 1,2 & Guido Di Dalmazi 1,2
1S. Orsola-Malpighi Polyclinic, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2S. Orsola-Malpighi Polyclinic, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy; 3S. Orsola-Malpighi Polyclinic, Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Alma Mater Studiorum - Università di Bologna, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy
Aim: To analyze the prevalence of anxiety and depression in a large cohort of adults affected by autoimmune diabetes and to identify the associated factors, stratifying them according to sex.
Methods: We administered to 553 patients with autoimmune diabetes the questionnaires: Hospital Anxiety and Depression Scale (HADS), Diabetes Distress Scale, Diabetes-related Quality of Life and Diabetes Treatment Satisfaction Questionnaire. We excluded 119 patients with missing HbA1c ±4 months from HADS administration or incorrect HADS compilation (final cohort, n=434).
Results: Anxiety was reported in 132/434 subjects (30.4%), depression in 47/434 (10.8%). The group with anxiety had a larger proportion of females, higher HbA1c (median 56 mmol/mol [IQR 49-63] vs 59 [IQR 52-66]; P=0.006), higher average HbA1c in the previous 36 months (56 mmol/mol [IQR 50-63] vs 59 [IQR 54-66]; P=0.002), more individuals with HbA1c >48 mmol/mol (76.8% vs 90.2%; P=0.001), more CGM users (61.3% vs 71.2%; P=0.046) and lower Time in Range (60.1% vs 54.8%; P=0.043). The group with depression showed higher median age (47 years [IQR 33-59] vs 53 [IQR 42-59]; P=0.015) and superior prevalence of cardiovascular diseases (3.1% vs 12.8%; P=0.002) and retinopathy (31% vs 46.8%; P=0.029). There was greater emotional distress, and lower quality of life and treatment satisfaction (P equal or inferior to 0.005, for all), irrespective of sex. In females, CGM use was and independent risk factor for anxiety and older age for depression; in males elevated levels of Hb1Ac (a worse glycemic control) were an independent risk factor for both anxiety and depression. No differences in CGM-derived metrics were observed stratifying results by sex.
Conclusion: Nearly 1/3 of the patients with autoimmune diabetes suffers from anxiety and nearly 1/10 from depression. These conditions are associated with independent modifiable and non-modifiable characteristics, which are different between females and males.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more