Endocrine Abstracts

Lipodystrophy is a rare disease characterized by generalized or partial lack of adipose tissue. Lipodystrophy is associated with leptin deficiency and leads to severe insulin resistance and metabolic abnormalities. A previous literature review reported an estimated prevalence of less than one in a million based on the assumption that only one-fourth of the patients with lipodystrophy may have been reported. Later, the prevalence of lipodystrophy was estimated through a search ...