Endocrine Abstracts

Introduction : Jougerot –sjogreen syndrom is an auto-immune exocrinopathy secondary to the interaction between a favorable ground and environmental factors that can lead to the disease. Thyroiditis can precede sjogreen’s syndrom or follow it, just as the two diagnoses can be made at the same time.

Case report : 46-year-old female patient, type 2 diabetic on oral antidiabetic 2g/d, followed for sjogreen jougerot syndrom retained in the face of occulo-buccal dry syndrom, cervicothoracic pain, schirmer test positive salivary gland biopsy under corticosteroid therapy. On questionning, the patient reported inflammatory polyarthralgia associated with chronic constipation and asthenia. Objective physical examination morbid obesity with BMI=44 kg/cm², palpable thyroid increased in size. On the balance sheets TSH= 6.7uui/l, T4= 11pmol/l on the cervical ultrasound : homogenous thyroid, with regular contours, normo vascularized on the doppler seat at the left mid-lobe level hypoechogen formations formations measuring 12.6*7.3mm classified Eu-tirads 3, at the left lower lobe level hypoechogen formations measuring 9*7mm Eu-tirads 2with positive anti-TPO antibodies. The patient was put on levothyrox 75ug/d.

Discussion : Jougerot-sjogreen syndrom is a dysregulation of the immune system by B cell hyperactivation. It is probably the systemic autoimmun disease most frequently associated with autoimmun thyroiditis with an estimated prevalence of 20%. The strong association between the presence of thyroid antibodies for patients with autoimmun hypothyroidism with jougerot syndrom. The association does not seem to result from a disease caused by the other, but results from the appearance of entities to which a context genetically predisposes the subjects, such as patients with HLA DRW3 and HLAB8 haplotypes.

Conclusion : The jougerot sjogreen syndrom and auto-immun thyroiditis their association reflects the presence of a common genetic ground on which are added environmental factors which are added environmental factors which determine the clinical aspects. Regular assessment of thyroid function is necessary in any patient with jougerot sjogreen syndrom.