ECE2023 Eposter Presentations Reproductive and Developmental Endocrinology (48 abstracts)
Serum AMH in women with polycystic ovary syndrome
Jinju Kim 1,2 , Kyu Ri Hwang 2,3 , Sunmie Kim 1,2 & Young Min Choi 4,5
1Healthcare System Gangnam Center, Seoul National University Hospital, Obstetrics and Gynecology, Seoul, South Korea; 2Seoul National University College of Medicine, Obstetrics and Gynecology, Seoul, South Korea; 3SMG-SNU Boramae Medical Center, Obstetrics and Gynecology, Seuol, South Korea; 4Grace Hospital, Obstetrics and Gynecology, Goyang, South Korea; 5Seoul National University College of Medicine, The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul, South Korea
Background and Aims: Anti-Müllerian hormone (AMH) is secreted by granulosa cells of ovarian follicles. Since AMH reflects the number of antral follicles and the pronounced androgen secretion from follicles/stroma in women with polycystic ovary syndrome (PCOS) remains until late reproductive age, the age related relationship between AMH in women with PCOS are of interest.
Methods: Women with PCOS (aged 15–42 years) (n=537) participated in the study. AMH level according to age groups were investigated. The relationships between AMH and androgenic, metabolic, hormonal and ovarian parameters were also studied. Finally, multiple regression analysis was done to evaluate determinants of serum AMH level in women with PCOS.
Results: From 537 women with PCOS, 375 patients showed clinical and/or biochemical hyperandrogenism, and the remaining 162 patients did not show. Mean serum AMH level was significantly higher in hyperandrogenic patients (10.38 ng/ml, 95% CI, 9.71 - 11.09) compared with that of non-hyperandrogenic ones (8.74 ng/ml, 95% CI 7.98 - 9.58) (P= 0.004). Serum AMH levels showed no differences according to different age groups (Table 1) and remained stable throughout the ages (Figure 1). In Pearson’s correlation analysis, serum AMH showed significant positive correlations with total testosterone, free testosterone, log free androgen index, androstenedione, DHEAS, LH levels, mean antral follicle number and ovarian volume. A multiple linear regression model was used to determine variables which were associated with AMH level. Age did not contribute significantly to the model. Only LH, total testosterone, and mean antral follicle number contributed significantly to serum AMH levels.
Conclusions: Serum AMH levels remained high until late reproductive age and did not show significant variation according to the age groups. Hyperandrogenic PCOS patients showed higher AMH levels than that of non-hyperandrogenic patients. LH, total testosterone, and antral follicle number were main contributors to serum AMH levels irrespective of age
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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