Endocrine Abstracts

Non-secreting pituitary adenomas (NSPA) are relatively rare benign tumors their prognosis depends essentially on their endocrine and ophthalmological repercussions the aim of our study is to outline their clinical, biological, radiological aspects, and the therapeutic choice.

Methods: Retrospective study of 17 patients with non secreting pituitary adenomas.

Results: We identified 17 patients with NSPA split into 12 women and 5 men with a sex ratio of 2.3. The average age was 47 years (+/-16.9). The circumstances of discovery were pituitary insufficiency in 17.6% of cases, an incidentaloma in 11.8% of cases, and a tumor syndrome in 70.6% of cases. Patients presented with headaches in 76.5% of cases and a decrease in visual acuity was noted in 64.7% of cases.47.1% of MRI cases were macroadenomas with invasion of the optic chiasma in 41.2% of cases. Necrotic remodeling was observed in 23.5% of cases and hemorrhagic remodeling in 17.6% of cases. The hypophysiogram study showed gonadotropic insufficiency in 47.1% of patients, followed by corticotropic insufficiency in 35.3% of cases. A hyperprolactinemia of disconnection was noted in 17.7% of the cases surgery was indicated in 36.4% of the cases given the damage of the optic chiasma the evolution during the follow-up was marked by the appearance of a pituitary deficit or more in 17.6% of the patients.

Conclusion: NSPA are most often discovered due to a tumoral syndrome, generating a pituitary insufficiency essentially gonadotropic and corticotropic. The operative indication is set according to the size, the evolutivity and the proximity of the optic tracts.