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Endocrine Abstracts (2023) 90 EP863 | DOI: 10.1530/endoabs.90.EP863

University Hospital Center Ibn Rochd, Department of Endocrinology and Metabolic Diseases, Casablanca, Morocco


Introduction: Prolactin adenomas are the most common pituitary adenomas. Although the pituitary increases in size and the prolactinoma increase gradually during normal pregnancy; prolactinomas do not contraindicate pregnancy but require strict monitoring.

Goals: To study the impact of pregnancy on the development of prolactin pituitary adenomas.

Materials and methods: Retrospective descriptive cohort study conducted in the endocrinology department of the CHU Ibnou Rochd Casablanca in pregnant patients followed for prolactin pituitary adenomas

Results: We report 7 pregnancies in 5 women, whose average age is 33 years: there is a single micro adenoma and 4 macro adenomas, 4 patients had thyrotropic insufficiency and 2 patients had corticotropic insufficiency. The average duration of evolution before pregnancy was 4 years and all our patients were treated with cabergoline with an average dose of 1.5 mg/week. When the pregnancy was discovered, only one patient stopped the treatment. A pituitary MRI was performed on 3 of our patients during pregnancy objectifying a quasi-stable appearance of the adenoma. Two patients were complicated by gestational diabetes. The pregnancies were carried to term, vaginally in 3 cases and cesarean section in 3 patients ; 3 patients breastfed with good clinical evolution.

Conclusion: The evolution of prolactinomas during pregnancy is variable. This may justify the continuation of dopaminergic agonist treatment during pregnancy, with close monitoring.

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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