ECE2023 Eposter Presentations Pituitary and Neuroendocrinology (234 abstracts)
Early Left Ventricular Diastolic Dysfunction in Females with Chronic Hyperprolactinemia: a Doppler Echocardiographic Study
Alberto Maria Marra 1 , Michele Arcopinto 1 , Roberta D’Assante 1 , Valeria Valente 1 , Renata Simona Auriemma 2 , Giulia Crisci 1 , Federica Giardino 1 , Rosa Pirchio 2 , Rosario Pivonello 2 , Eduardo Bossone 3 , Annamaria Colao 2 & Antonio Cittadini 1
1University of Naples “Federico II”, Department of Translational Medical Sciences, Naples, Italy; 2University of Naples “Federico II”, Endocrinology Unit, Department of Clinical Medicine and Surgery, Naples, Italy; 3University of Naples “Federico II”, Department of Public Health, Naples, Italy
Despite the myocardial prolactin (PRL) binding activity and the known effect to enhance contractility in the isolated rat heart, little information is available concerning the cardiovascular consequences of hyperprolactinemia in humans. To elucidate the effects of chronic hyperprolactinemia on cardiac structure and function, twenty-four patients with isolated PRL-secreting adenoma and twenty-four controls underwent a complete mono- and two-dimensional Doppler echocardiography. Blood pressure and heart rate were similar in the two groups, and no significant differences were observed as to left ventricular (LV) geometry between patients and controls. Resting LV systolic function was normal in patients with hyperprolactinemia, as shown by similar values of fractional shortening and cardiac output. Conversely, hyperprolactinemic patients exhibited a slight impairment of LV diastolic filling, as demonstrated by the prolongation of the isovolumetric relaxation time and the increase of the atrial filling wave of mitral Doppler velocimetry (58±13 vs 47±8 cm s−1, P<0.05) with a subgroup of females (16%) having a clear diastolic dysfunction, and a worse exercise capacity (6 min walking test 452±70 vs 524±56; P<0.05). In conclusion, hyperprolactinemia in humans may be associated with slight impairment of diastolic function, with an overt diastolic dysfunction in a subgroup of females which correlated with poorer exercise performance, in the absence of significant abnormalities of LV structure and systolic function.
| Hyperprolactinemia n=24 | Control n=24 | |
| Aortic root (mm) | 30±3 | 28±3 |
| Left atrium volume index (ml/m2) | 27±7* | 22±6 |
| IS diastole (mm) | 9±2 | 9±1 |
| PW diastole (mm) | 8±7 | 8±1 |
| LV-EDD (mm) | 48±3 | 48±3 |
| LV-ESD (mm) | 29±3 | 29±3 |
| LV Mass (g) | 163±52 | 169±40 |
| Fractional shortening (%) | 39±5 | 39±5 |
| LV ejection fraction (%) Cardiac output (l/min) TAPSE (mm) | 61±3 5.3±1 22±4* | 60±2 5.5±1 25±3.6 |
| Peak TR velocity (m/sec) IRT (ms) | 2.5±0.6* 93±15 | 2.1±0.4 75±9 |
| Mitral DT (ms) | 147±28 | 142±27 |
| Mitral E/A ratio Mitral E/E’ ratio LV diastolic function: normal diastolic function (n, %) undetermined function (n, %) diastolic dysfunction (n, %) 6 MWD (m) | 1.44±0.46* 7.8±1.9* 14 (58.4)* 7 (29.1)* 3 (12.5)* 515±60* | 1.66±0.25 6.4±2.0 23 (95.8) 1 (4.2) 0 (0) 610±54 |
| IS=interventricular septum; body surface area; PW=posterior wall; LV=left ventricular; EDD=end-diastolic dimension; ESD=end-systolic dimension; IRT=isovolumic relaxation time; DT=deceleration time; E=mitral early peak flow velocity; A=mitral late peak flow velocity; 6 MWD: 6 min walking distance; *=P<.05 vs controls. | ||
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more