ECE2023 Eposter Presentations Endocrine-related Cancer (80 abstracts)
Neuroendocrine tumors of the head and neck: our experience
Houas Jihene 1 , Kechiche Jawaher 1 , Ghammam Monia 1 , Belhadjmiled Heyfa 1 , El Omri Malika 1 , Bellakhdher Mouna 1 , Hasni El Abed Yosra 2 , Meherzi Abir 1 , Kermani Wassim 1 & Abdelkefi Mohamed 1
1ENT Department and Neck Surgery of Farhat Hached Hospital, Sousse, Tunisia; 2Endocrinology Department Farhat Hached Hospital, Sousse, Tunisia.
Introduction: Neuroendocrine tumors of head and neck region are rare and heterogeneous. it can arise in all the different organs of this region, including the nasal cavity, paranasal sinuses, larynx, thyroid, can be divided into two broad groups: those with epithelial differentiation, and neurally derived tumours, including paragangliomas and olfactory neuroblastomas. Their morphological and clinical features mainly depend on the degree of differentiation and on the site of origin.
Method: A retrospective study was conducted on 37 patients identified with neuroendocrine tumors of the head and neck over a period of 32 years, from 1990 to 2022. Presentation, Clinical examination, evaluation, medical and surgical treatments, histological examination were reviewed.
Results: The average age was 44 years ranging from 11 to 83 years with a sex ratio of 1.2. The average consultation delay was 8 months. We identified 12 patient with paraganglioma and as chief complaint of neck mass, Olfactory neuroblastoma in 7 cases presented with epistaxis and nasal obstruction, neuroendocrine tumors arising from the larynx in 5 cases, consulted for dysphonia and dysphagia, medullary thyroid carcinoma in 12 cases and neuroendocrine carcinoma of the thyroid in 1 case presented for cervical swelling. Treatment courses varied across patients and included combinations of surgery, and/or radiotherapy. Average follow-up time was 2 years. 6 Patients were lost to follow-up. 2 had evidence of known metastases to various sites including bone, and brain. A tumor recurrence was noted in 5 cases.
Conclusion: Neuroendocrine tumors are a heterogeneous group of neoplastic proliferations showing different morphological features, clinical presentation, and treatment outcomes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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