ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Lipemia interferences in clinical biochemistry parameters: a case report
Ines Mezghani 1 , Rim Marrakchi 1 , Faten Hadj Kacem 2 , Mariem Boudaya 1 , Mariem Gassara 1 , Kaouthar Feki 1 , Kamel Jammoussi 1 , Mohamed Abid 2 & Mouna Turki 1
1Hedi-Chaker University Hospital of Sfax, Biochemistry Department, Sfax, Tunisia, 2Hedi-Chaker University Hospital, Tunisia, Endocrinology Department, Sfax, Tunisia
Introduction: Lipemic specimens could be a source of significant analytical errors. The aim of this study was to examine the effect of lipid removal using ultra-centrifugation of lipemic samples, on some routine biochemistry parameters.
Observation: A 53-year-old man hospitalized in endocrinology department for treatment of severe hypertriglyceridemia (21.3 mmol/l). All the patient’s routine biochemical parameters were held on AU 680® Beckman Coulter before and after ultracentrifugation of the plasma sample. We determined total bilirubin, glucose, gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (PAL), amylase, lipase, creatine kinase (CK), lactate dehydrogenase (LDH), iron, cholesterol, triglycerides, HDL cholesterol, phosphorus, creatinine, urea, total protein, albumin, uric acid and magnesium. The percentage of differences (bias) was calculated and compared with the allowable inaccuracy. Clinically significant interferences were found in AST (14.81%), Total bilirubin (23.08%), lipase (27.06%), Total protein (1.47%) and magnesium (12.5%).
Conclusion: Lipemia causes clinically significant interferences for AST, Total bilirubin, lipase, Total protein and magnesium measurement on AU 680® Beckman Coulter and those interferences could be effectively removed by ultracentrifugation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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