Endocrine Abstracts

Aim of the study: To study the lipid profile of patients with diabetes mellitus 2 type (DM 2) and morbid obesity before bariatric surgery.

Material and methods: We evaluated 35 patients (15 women, 20 men) with DM 2 type and morbid obesity during October-December 2021. Mean age of patients was 48.3 years-old. Control group constituted by 20 healthy patients with same age. The patients were divided by BMI into 2 groups:

Group 1 – 17 patients with grade II obesity

Group 2 – 18 patients with grade III obesity

All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (TSH, LH, FSH, prolactin, free testosterone, estradiol, progesterone, prolactin, etc), genitalia’s ultrasonography, height (sm), weight (kg), BMI, waist circumference (WC), hip circumference (HC), waist–hip ratio, questioning and other studies.

Results: The study of anthropometry indicators revealed that 3 degree of obesity in all groups dominated: in 1 gr - 64% of patients, 2 gr – 68%. The biochemical profile studies revealed violations of lipid metabolism – 84.6%: hypercholesterolemia –73.1%, reduced level of high density lipoproteins (HDL) – 73.1%, increased maintenance of low density lipoproteins (LDL) – 55.8%, hyperitriglyceridemia – 34.6%. A carbohydrate exchange disorders were found in all groups – insulin resistance – 88.5% of the total number of patients, hyperinsulinemia – 76.9%, violation of glucose tolerance – 46.2%.

Conclusions: 1. In patients with Morbid obesity, 3 degree of obesity dominated in all surveillance groups. 2. The biochemical profile studies revealed violations of lipid metabolism – 84.6%: hypercholesterolemia – 73.1%, reduced level of HDL – 73.1%, increased maintenance of LDL – 55.8%, hyperitriglyceridemia – 34.6%