Endocrine Abstracts

Objective: Post Covid Syndrom (PCS) after Covid Pamdemic is a major couse of morbidity for Diabetic patients. In the last 30 years, a new metabolic risk factor for vascular damage – hyperhomocysteinemia (HtHcy) has been identified and is considered as an independent risk factor for the development of cardiovascular pathologies and the possible lethal outcome.

Aim of study: This study was undertaken to check association of plasma Hcy level in post covid diabetics with increased risk of CVD. That’s why, due to the growing number of patients with T2DM with Long Covid symptoms and complications we decided to study non-insulin-dependent diabetics in this area to determine the correlation between Covid infection and HtHcy and give some evidence about correlation between CVD high risk.

Keywords: homocysteine; Post Covid Syndrome (Pcs), plasma, type 2 diabetes mellitus, cardiovascular disease CVD.

Method and design: Case-control study, was conducted to assess the effect on plasma homocysteine (Hcy) in 74 type 2 diabetic out-patients with anamnesis of Covid 19 only who did not require hospitalization for COVID-19 disease were included this study. Clinical data and laboratory results of 74 RT-PCR-positive COVID-19 cases were collected, aged between 65> years old man and woman, ambulatory visited 6 endocrinologist and 3 cardiologists in 3 primary care clinic, city Batumi, period between March 10 – to November 23, 2022. 34 of these patients had a history of cardiovascular complication, or Heart Bypass Surgery CABG(7 pts) before Covid-19 disease. Test results of metabolite panel: B12, folate and homocysteine, which were run in the immunochemistry module of Cobas^®8000 analyzer using Electro Chemi Luminescence technology (Roche diagnostics, Mannheim, Germany).

Results: 74 Post COVID-19 diabetic patients (43 males, 31 females) were enrolled in the study. Laboratory results: Homocysteine (μmol/l) – 15.62±1.37; Folate (mg/l) – 4.59±0.41; B12 (ng/l) –531.50±62.20.

Summery points: Hyperhomocysteinemia was observed in post COVID diabetic patients included in the study; We recommend analysis of homocysteine levels to predict the course of the post Covid syndrome; Homocysteine levels in post COVID-19 NIDDM patients can be evaluated for a predictive, preventive and personalized medical approach.

Conclusion: Homocysteine levels can be used as a prognostic parameter that can predict the severity of post COVID-19 disease. We believe that studies on disease severity and predictive medicine in the field of biomarkers will increase in the future.

Competing interests: Authors state no conflict of interest.