Endocrine Abstracts

Type 2 diabetes is a progressive chronic disease that is on a global upward trend and involves high healthcare costs. Obstacles to adaptation to this disease include knowledge of the disease, fear of treatment, inability to adapt to changes in lifestyle, lack of physical activity and exhaustion. Type 2 diabetes significantly affects brain function, including cognitive function, and increases the risk of depression. The studies reveal that there has been no comparison of neurological changes in healthy people over the lifespan experienced by diabetics of the same age. Cognitive dysfunction mechanisms are multifactorial. It is affected by age, disease duration, HbA1c, comorbidities and medications. Depression is a very common problem in type 2 diabetes and has a multi-directional effect. Depression can trigger type 2 diabetes and develop depression in type 2 diabetes. The mental health problem worsens coping, and quality of life and increases mortality rates. Depression is often undiagnosed or inadequately treated for this disease. Psychosocial problems include a person’s attitudes towards diabetes, expectations of treatment and outcomes, mood changes, available resources, and psychiatric background. To detect early symptoms of depression, we can use non-invasive methods, one of which is brain ultrasound. For an objective assessment of sleep disorders, it is possible to use melatonin determination in urine, which is simple and easily available. The purpose of the study is to examine the changes in the raphe nuclei in the brain, melatonin levels in urine, along with mental health and sleep quality questions and comprehensive background data in people with type 2 diabetes. A double-blind controlled study of barriers to adjustment to illness in people with type 2 diabetes. The sample consists of (n=600) people with type 2 diabetes and their relatives in the control group. Data are collected during one year from the regional hospital and private health center included in the study. As a result of the study, we get evidence of the changes in the Raphe nuclei of the brain for comparison with the results of the Moca test, and the change in the melatonin level in cognitive disorders in people with type 2 diabetes.

Keywords: type 2 diabetes, adaptation barriers, psychosocial problems, complications, depressioon, cognitive impairment