Endocrine Abstracts

Metabolic syndrome (MS) is characterized by obesity, hypertension, dyslipidemia, and insulin resistance. The severity of the clinical manifestations of MS affects the quality of life (QoL) of patients, while indicators of physical and mental health decrease. In patients, anxiety and depressive disorders in 80-90% of cases are latent, which can aggravate the course of the underlying disease. The purpose of our work is to study the psycho-emotional status and quality of life in patients with metabolic syndrome.

Research Methods: The study was conducted on the basis of the clinic of the Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS. All patients were divided into groups: group 1 - 76 patients with MS, group 2 - 42 practically healthy volunteers without concomitant diseases and not obese. Patients were examined with determination of anthropometric parameters: waist circumference (cm), body weight (kg), BMI (kg/m²). The assessment of the quality of life was determined using the SF-36 questionnaire. The level of anxiety and depression was assessed in points according to the hospital anxiety and depression scale HADS (1983).

Results: According to the obtained results, the majority of QoL indicators differed statistically significantly in the group of patients with MS relative to the control group (Group 2). Thus, the indicators of the level of QoL are significantly higher in healthy individuals than in patients with obesity. Differences in all groups are significant (p≤0.05). It was also found that a decrease in the average level of parameters on the scale "physical functioning" by 19.7% (P<0.05), "role functioning" by 35.2% (P<0.05), "general health" by 15, 1% (P<0.05), "vitality" by 18% (P<0.05), "emotional functioning" by 53.1% (P<0.05). The assessment of the level of anxiety and depression in patients with MS corresponded to a subclinically expressed level, and the level of depression exceeded the indicator of the control group (Group 2) by 19.3%. The level of QoL in patients with obesity is significantly lower than in healthy individuals.

Conclusion: The obtained results show that in patients with MS, quality of life indicators decrease, most patients have significant changes in the state of the psycho-emotional sphere, subclinical anxiety-depression is determined. Also, patients require correction of psychological disorders, which will reduce the level of anxiety and depressive disorders, which will further improve the quality of life.