Endocrine Abstracts

We evaluated the relationship between blood glucose and urine glucose levels in type 2 diabetes (T2D) patients who had reached steady state upon taking a sodium-glucose co-transporter-2 inhibitor (SGLT-2 inhibitor). Ten patients with T2D taking Luseogliflozin 2.5 mg for more than 2 weeks were hospitalized for diabetes treatment. During hospitalization, the patients used a continuous glucose monitor (CGM) [iPro2] for 6 days (CGM attachment: day 1) while continuing Luseogliflozin 2.5 mg intake. All other antidiabetic treatments were adjusted to improve glycemic variability. From day 2 to day 5, starting from 9 AM, we obtained four consecutive 24-hour mean blood glucose levels (24-h MGL) and 24-hour urine glucose levels (24-h UGL), respectively. “24-h MGL and 24 h-UGL during the same period” (paired MUGL) were compared. We arranged paired MUGL in descending order of 24-h MGL. Then, consecutive 20 paired MUGLs were selected while shifting selection start one by one. Estimated glomerular filtration rate (eGFR) was measured once during hospitalization. For each selected group, we used multivariate linear regression analysis to predict the 24-h UGL from the 24-h MGL and eGFR, where we commonly applied eGFR as a pair for the four paired MUGLs per each patient. One paired MUGL was excluded from the analysis due to inaccurate urine glucose measurement. The arranged paired MUGL were numbered from 1 to 39 and consecutive 20 paired MUGLs were selected 20 times (from “1–20” to “20–39”: 20 groups). 24-h MGL positively correlated with 24-h UGL (r=0.81; n=39). For the results analyzed using multivariate linear regression analysis in each group, standard partial regression coefficient (β) for eGFR, β for 24-h MGL, p for eGFR, p for 24-h MGL, adjusted-R2 for a regression formula (RF), and p for RF correlated with mean of 24-h MGL in each group (r=–0.61, –0.76, 0.72, 0.62, –0.62, and 0.62, respectively; n=20). Under steady state for SGLT-2 inhibitor in T2D, decreased 24-h MGL may be associated with decreased 24-h UGL. Increased 24-h MGL could lead to a reduced ability of predicting 24-h UGL using both 24-h MGL and eGFR.