Endocrine Abstracts

Introduction: Past years with increasing of duration of life, improving of treatment and increasing of life longevity and new knowledges about Diabetes Mellitus pathogenesis and treatment rise interest to reproduction in these women, especially with type 1 DM. Well known, that late puberty, abnormal menstrual cycle, pregnancy and childbirth pathology, infertility. The aim of our study was investigate the functional state of reproductive system in woman with DM1.

Material and Methods: 72 control female patients with type 1 diabetes and 40 healthy women were examined. The age of the examined patients ranged from 11 to 28. In all female patients blood plasma FSG, LG, Estrogen, Progesterone, Testosterone level were determined by the enzyme immunoassay method, uterine and ovarian Ultrasound were performed.

Results: In patients with DM1 blood plasma level of Estrogen were decreased in 60% of them, Progesterone - in 24%, Testosterone - in 45%, whereas FSG and LG levels were increased and suggested about hypergonadal hypogonadism in women with DM1. Anamnesis data shown among women with DM1 about 44% had amenorrhea, 16% had infertility, 11% had stillbirth, and 9% had premature birth. On ultrasound examination of the uterus and ovaries in women with DM1 shown that 20% had uterine hypoplasia and was in line with blood hormones level.

Conclusion: In observed woman with DM1 according to anamnestic data shown abnormalities in functional state of reproductive system such as amenorrhea (44%), infertility (16%), stillbirth (11%), premature birth (9%), which accompanied with decreasing of peripheral sex hormones level and increasing of pituitary hormones and uterine hypoplasia (20%) on ultrasound suggested about hypergonadal hypogonadism.