Endocrine Abstracts

Objective: To assess the predictive factors for the occurrence of urinary dysfunction (UD) in patients with diabetes mellitus (DM).

Patients and Methods: Case-control study comparing two groups of patients suffering from DM: G1 (n=159) with UD vs G2 (n=41) without UD.

Results: G1 patients were older than G2 patients (59.7±10.3 vs 58±12 years) with no significant difference in gender. The duration of diabetes was significantly longer in G1 (11.9 vs 7.7 years; P=0.03). G1 patients were significantly more frequently insulin-requiring (62% vs 42.5%; P=0.025) but with an obvious delayed switch to insulin than G2 (7.6 vs 2.6 years; P=0.011). Mean HbA1C was statistically significantly worse in G1 (9.5% vs 8%; P=0.01). Microvascular complications were more reported in G1 (P=0.021). Macroangiopathy did not appear to be associated with UD in our series (P=0.07). The multivariate analysis identified long-standing diabetes (OR=1.07; P=0.033; CI95%=[1.01-1.16]), HbA1C>7% (OR=0.38; P=0.045; CI95%=[0.15-0.57]) and peripheral neuropathy (OR=6.43; P=0.000; CI95%=[2.39-17.28]) as independent predictive factors for the development of UD in patients presenting with DM.

Discussion: A preventive strategy against the onset of UD in patients with DM should be considered by acting on modifiable predictive factors. The pillars of this strategy would be earlier detection of diabetes, more effective glycaemic control, timely use of insulin therapy, and delaying the onset of chronic complications.

References: 1. Guiming, Liu, and Daneshgari Firouz. "Diabetic bladder dysfunction." Chinese medical journal 127.07 (2014): 1357-1364.

2. Wittig, Luc, et al. "Diabetic bladder dysfunction: a review." Urology 123 (2019): 1-6.