ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Arterial stiffness in patients with type 2 diabetes mellitus at different stages of diabetic nephropathy
Nodira Alikhanova 1 , Charos Musakhanova 1 , Nozimakhon Nazarova 1 , Rifqat Davronov 2 , Feruza Takhirova 1 , Gulzoda Akramova 1 , Lola Abboskhujaeva 1 , Shakirova Munavvara 1 , Raisa Trigulova 3 , Durdona Kayumova 1 , Mokhira Aykhodjaeva 1 & Nigora Maksutova 1
1Republican Specialized Scientific and Practical Medical Center of Endocrinology named after academician Y.Kh. Turakulov, Tashkent, Uzbekistan; 2V.I. Romanovsky Institute of Mathematics, Academy of Sciences, Tashkent, Uzbekistan; 3Republican Specialized Scientific and Practical Medical Center for Cardiology, Tashkent, Uzbekistan
Background and Aims: Arterial stiffness is associated with increased risk for target organ damage, cardiovascular events and overall mortality in the general population, patients with diabetes mellitus (DM) and patients with chronic kidney disease (CKD) of all stages. The aim of this study is assessment of pulse wave velocity (PWV) in patients with type 2 diabetes at different stages of diabetic nephropathy and without it.
Materials and Methods: We examined 138 patients with DM type 2 aged 18 to 70 years. We divided the patients into two groups: the control group - patients without CKD and the main group - patients with CKD. The main group was also divided into 5 groups according to CKD stages by KDIGO (2012). In addition to routine tests for the diagnosis of CKD, we performed sphygmography (SphygmoCor XCEL, AtCor). Informed consent was obtaining from each patient prior to the study. To exclude the effect of smoking on arterial stiffness, former and current smokers were excluded from the study.
Results: Patient’s average age was 51.6±8.6 years in control group and 60.25±8.05 years in main. The average duration of diabetes was 6.56±4.8 years in control and 12.87±7.34 years in main group. 55% of them were women (n=76) and 45% were men (n=62). Spearman’s rank correlation analysis revealed a significant relationship between the PWV and age of the subjects (r=0.4; P<0.001); the duration of diabetes (r=0.3; P=0.01); estimated glomerular filtration rate (r=0.4, P=0.004) (Table 1). When examining subjects by age group, it was found that DM2 patients with CKD of the same age had a higher PWV compared to the control group (Table 2).
Discussion: Diabetic CKD patients present higher arterial stiffness than non-CKD counterparts do. With an increase in the stages of CKD and age, the PWV also increased. These finding suggest that the presence of CKD is another factor further contributing to the adverse profile of the macrocirculation in DM patients.
| Group | n= | PWV (m/s) |
| Control | 33 | 8.39±1.50 |
| CKD 1 | 24 | 9.06±2.20 |
| CKD 2 | 21 | 9.89±2.67 |
| CKD 3 | 25 | 10.14±2.27 |
| CKD 4 | 15 | 10.41±2.31 |
| CKD 5 | 20 | 10.75±2.34 |
| Age | Control | Main | P= |
| 60< | 9.6±1.2 | 10.5±2.3 | <0.05 |
| 45-59 | 7.9±2.1 | 9.3±2.4 | <0.05 |
| 18-44 | 7.7±1.8 | 8.2±2.1 | <0.05 |
Keywords: diabetes mellitus, chronic kidney disease, pulse wave velocity, arterial stiffness
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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