ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Prediabetes remission after bariatric surgery: A 4-years follow-up study
Marta Borges-Canha 1 , Joao Sergio Neves 1 , Maria Silva 1 , Fernando Mendonça 1 , Telma Moreno 1 , Sara Ribeiro 1 , Catarina Vale 1 , Juliana Gonçalves 1 , Helena Urbano Ferreira 1 , Sara Santos 2 , Raquel Calheiros 2 , Inês Meira 1 , João Menino 1 , Vanessa Guerreiro 1 , Jorge Pedro 1 , Ana Varela 1 , Selma Souto 1 , Eduardo Lima da Costa 1 , Paula Freitas 1 , Davide Carvalho 1 & CRIO Group 1
1Centro Hospitalar E Universitário De São João, Porto, Portugal; 2Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Portugal
Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.
Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.
Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bariatric surgery in our centre between January 2010 and December 2021. Prediabetes was defined as having baseline glycated haemoglobin (A1c) between 5.7% and 6.4% and absence of anti-diabetic drug treatment. We excluded patients submitted to gastric band surgery, or without A1c at baseline or first year of follow-up. We used logistic regression models to evaluate the association between the predictors and prediabetes remission rate.
Results: A total of 699 patients were included, 84% being female. The population had a mean age of 45.4±10.1 years-old, body mass index of 43.8±5.7 kg/m2, and median A1c of 5.9 [5.8, 6.1]%. After bariatric surgery, prediabetes remission rate was 82%, 73%, 66%, and 58%, respectively at the 1st, 2nd, 3rd, and 4th years of follow-up. Gastric sleeve (GS) surgery associated to higher prediabetes remission rate than Roux-en-Y gastric bypass (GB) surgery since the 3rd year of follow-up. Men had a higher remission rate than female, except at 2nd year of follow-up. Younger patients presented a higher remission rate comparing to older patients since the 3rd year of follow-up.
Conclusion: Our results show a high prediabetes remission rate after bariatric surgery. The remission rate decreases along the follow-up period, although most of the patients uphold the normoglycemia. Prediabetes remission seems to be more significant in patients submitted to GS, male and younger patients. These results help to fill the gap in knowledge regarding the effect of bariatric surgery in prediabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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