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Endocrine Abstracts (2023) 90 EP234 | DOI: 10.1530/endoabs.90.EP234

ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)

Influence of metabolic factors on the course of the acute period of COVID-19 in hospitalized patients according to the international registry ACTIV SARS-CoV-2

Alexander Arutyunov 1,2 , Elizaveta Gordeychuk 3 , Roman Bashkinov 4 , Tatiana Batluk 3 , Evgenii Melnikov 4 & Marina Trubnikova 5


1National Institute of Health after academician S. Avdalbekyan, Erevan, Armenia; 2Eurasian Association of Internal Medicine, "ACTIV SARS-CoV-2" Working Group, Erevan, Armenia; 3Eurasian Association of Internal Medicine, "ACTIV SARS-CoV-2" Working Group, Moscow, Russia; 4Eurasian Association of Internal Medicine, "ACTIV SARS-CoV-2" Working Group, Saint Petersburg, Russia; 5Eurasian Association of Internal Medicine, "ACTIV SARS-CoV-2" Working Group, Sochi, Russia


Background: The literature shows that body mass index (BMI) and blood glucose levels can significantly influence the course of infectious diseases. In the light of ongoing SARS-CoV-2 pandemic, its rational treatment and prevention are strategic public health goals.

Aim: To study the relationship between BMI and serum glucose levels during the acute period of COVID-19 in hospitalized patients.«ACTIV SARS-CoV-2» registry was established to evaluate the course of COVID-19 in the Eurasian region and covered 7 countries. ACTIV (NCT04492384) and ACTIV 2 (NCT04709120) are multicenter non-interventional real-world registries. 6396 subjects from ACTIV and 2968 subjects from ACTIV 2 were included in this study.

Results: Patients with higher serum glucose levels and BMI had significantly more severe acute period of COVID-19, characterized by acute kidney injury (AKI), hyperinflammatory syndrome, increase in C-reactive protein (CRP) above 100 mg/l, or need for targeted therapy (Table 1). Moreover, hyperglycemia at 6.9 (5.6–9.18) mmol/l was significantly (P<0.001) associated with death in the acute period (versus 5.7 (5.0–7.0) mmol/l in the survivors).

Table 1 Severity of Acute COVID-19 by Serum Glucose Levels and BMI
Characteristics of acute COVID-19Metabolic factorAbsent Ме (Q1 – Q3)Present Ме (Q1 – Q3)P
AKIGlycemia, mmol/l5.8 (5.0–7.0)6.0 (5.2–8.55)0.011
BMI, kg/m227.8 (24.8–31.6)29.6 (25.1–33.5)0.018
“Cytokine storm”Glycemia, mmol/l5.7 (5.0–6.6)6.1 (5.2–8.0)<0.001
BMI, kg/m227.5 (24.4–31.2)28.7 (25.6–32.8)<0.001
CRP above 100 mg/dlGlycemia, mmol/l5.4 (4.8–6.7)6.1 (5.0–8.1)<0.001
BMI, kg/m227.7 (24.7–31.7)28.7 (25.5–32.7)<0.001
Need for targeted therapyGlycemia, mmol/l5.8 (5.0–7.1)6.3 (5.4–8.0)<0.001
BMI, kg/m227.7 (24.7–31.3)29.7 (26.3–34.2)<0.001

Conclusions: Analysis of the ACTIV SARS-CoV-2 registry showed that patients with a more severe course of the acute period of COVID-19 in the form of AKI, “cytokine storm”, increase in CRP above 100 mg/l, or need for targeted therapy had higher serum glucose levels and BMI. In addition, hyperglycemia was associated with death during hospitalization for SARS-CoV-2. These findings allow the studied clinical parameters to be used as characteristics of the severe course of the disease.

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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