Endocrine Abstracts

Introduction: Primary hyperparathyroidism is a frequent pathology, its association with papillary thyroid carcinoma is rare.

Case Report: A 53 year old patient was admitted for management of primary hyperparathyroidism. The biological work-up showed a blood calcium level of 120 mg/l, parathyroid hormone (PTH) 4 times the normal range and hypophosphatemia. Cervical ultrasound showed a right parathyroid nodule with thyroid nodules classified Tirads 4, MIBI scintigraphy had objectified 2 right upper and lower parathyroid adenomas. The patient benefited from a right parathyroidectomy with isthmolobectomy, the anatomopathological study concluded to a parathyroid adenoma with main cells associated with a papillary carcinoma of the thyroid.

Discussion: The association between primary hyperparathyroidism and papillary thyroid carcinoma has been reported in 2.4-4.3% of patients with primary hyperparathyroidism. For some, this association could be explained by the embryological origin and shared genes. This observation illustrates the interest of the "check up" of the thyroid before any parathyroid surgery for a better management.

References: 1. Cetin K et al. Does primary hyperparathyroidism have an association with thyroid papillary cancer? A retrospective cohort study. Word J surg 2019; 43(5): 1243-8.2. Beebeejaun M et al. Papillary carcinoma of thyroid in patient with primary hyperparathyroidism: is there a link? Med Hypothese 2017; 103:100-4.