ECE2023 Eposter Presentations Adrenal and Cardiovascular Endocrinology (124 abstracts)
Adrenocortical vascular network and hormonal output after daidzein application in a rat model of the mild andropause
Jovana Cukuranovic Kokoris 1 , Miodrag Djordjevic 2 , Marko Miler 3 , Jasmina Živanović 3 , Jelena Marković-Filipović 4 , Dobrila Stanković Đorđević 5 , Rade Čukuranović 1 , Verica Milošević 1 , Branko Filipović 3 & Vladimir Ajdžanović 3
1University of Niš, Faculty of Medicine, Department of Anatomy, Niš, Serbia; 2University of Niš, Faculty of Medicine, Department of Surgery and Anesthesiology with Resuscitation, Niš, Serbia; 3Institute for Biological Research “Siniša Stanković”– National Institute of the Republic of Serbia, Belgrade, Serbia; 4University of Novi Sad, Faculty of Sciences, Novi Sad, Serbia; 5University of Niš, Faculty of Medicine, Department of Microbiology with Immunology, Niš, Serbia
Soy isoflavone daidzein exerts some beneficial effects in different ageing-related, chronic diseases and may represent a promising alternative to classical estrogenization of the prostate cancer suffering subjects. The aim of this study was to examine the effects of daidzein on the adrenocortical vascular network and hormonal output in a rat model of the mild andropause. Adult (3 months old) Wistar rats were divided into sham-operated (SO; n=7), orchidectomized (Orx; n=7) and daidzein treated orchidectomized (Orx+D; n=7) groups. Daidzein (30 mg/kg b.m./day) was administered subcutaneously for three weeks, while the SO and Orx groups received the vehicle alone. Adrenocortical vascular network properties were identified using Novelli histochemical staining, vascular endothelial growth factor (VEGF) immunostaining and the newCast stereological software. Blood concentrations of aldosterone, corticosterone and DHEAS were measured by immunoassays. Volume densities of blood vessels and VEGF depots within the adrenal cortex were not significantly changed after daidzein treatment, although there was a tendency of decrease of these parameters. On the other hand, daidzein application increased (P<0.05) blood concentration of aldosterone by more than 2.5 times and 41%, in comparison with the same parameter in sham-operated and orchidectomized group, respectively. Corticosterone concentration in daidzein-treated, orchidectomized rats showed a tendency of elevation (P>0.05) compared to the both SO animals and orchidectomy alone. DHEAS blood concentration after daidzein application remained at the level of the Orx group, which in both cases ment elevation (P<0.05) by around 80% in comparison with the same parameter in SO group. We conclude that daidzein significantly increases aldosterone and to some lower extent corticosterone output in a rat model of the mild andropause, without significant rearrangements of the entire adrenal cortex vascular network.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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