ECE2023 Eposter Presentations Adrenal and Cardiovascular Endocrinology (124 abstracts)
Effects of high-dose atorvastatin treatment on adrenal steroidogenesis in type 2 diabetes patients
Ameni Terzi 1 , Nadia Khessairi 1 , Ibtissem Oueslati 1 , Meriem Yazidi 1 , Hammami Bassem 2 , Fatma Chaker 1 , Feki Moncef 2 & Melika Chihaoui 1
1Rabta, Endocrinology, Tunisia; 2Rabta, Biochemistry, Tunisia
Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.
Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, and in whom the indication of a treatment with high dose of statin was indicated. The patients had two visits, before and six months after the daily intake of 40mg of atorvastatin. During each visit, they underwent a clinical examination and a fasting blood sample was collected for biological and hormonal measurements including cortisol and DHEA-S.
Results: The median age was 58 years (IQR: 52-62). The median body mass index was 29.5 kg/m2. The prevalence of asthenia, anorexia, and orthostatic hypotension increased significantly after statin intake from 35%, 12%, and 17% to 38%, 23%, and 18%, respectively. A decrease of 51.1% in median LDL-cholesterol was noted after statin administration. The median serum cortisol level was 289 nmol/l (IQR: 242-384) before and 301 nmol/l (IQR: 236-357) after atorvastatin intake (P=0.371). The median DHEA-S level decreased significantly from 4.5 µmol/l (IQR: 2.8-6.1) to 3.8 µmol/l (IQR: 2.6-5.6) after statin intake (P=0.005). The reduction of DHEA-S was significantly correlated with the reduction of LDL-cholesterol (r=0.262, P=0.043).
Conclusion: Long-term high-dose atorvastatin treatment in patients with type 2 diabetes did not impair serum cortisol levels but reduced DHEA-S levels.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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