Endocrine Abstracts

Background: Cervical neuroendocrine carcinomas (CNECs) are a rare and heterogeneous group of cervical neoplasms, with very limited data regarding epidemiology and survival. In this study, we explored clinicopathologic factors and oncologic outcomes of patients with CNECs derived from the Survival, Epidemiology and End Results (SEER) database, in comparison to cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC).Methods: The SEER database (18 re...

Background: Islet cell carcinomas are low-grade tumors originating from the islets of Langerhans. Despite the indolent nature of these tumors, metastasis is often detected upon initial diagnosis, at which point the mean survival is approximately 2 years. In this study, we aim to investigate disparities that exist in these patients and how facility variables, patient demographics, and palliative care (PC) utilization contribute to differences in survival outcomes.<p class="...

Background: Islet cell carcinoma is a rare cancer of neuroendocrine origin. There has yet to be a study analyzing the treatment type and survival outcomes in this cancer. In this study, we utilized a national database to understand the correlations between patient demographics, socioeconomic factors, modality of treatment, and survival.Methods: The National Cancer Database was queried to identify patients diagnosed with islet cell carcinoma (ICD-O-3 hist...

Background: Carcinoid heart disease (CHD) is a complication of neuroendocrine tumors (NETs). While its pathophysiology and manifestations are described, little is known about its occurrence in all patients diagnosed with NETs. We examined the occurrence of CHD and explored the use of echocardiography after diagnosis of NET.Methods: We conducted a population-based retrospective cohort study of adults diagnosed with small bowel and lung NETs (2000-2019). C...

Background: More than 12,000 people are diagnosed with neuroendocrine malignancies each year in the US. There are limited data on YO-NETs/YO-NECs. In the present study, we seek to evaluate clinical characteristics/trends of patients with GI-YO-NETs and GI-YO-NECs.Methods: Using the National Cancer DataBase, NCDB, we identified 124,081 GI-NETs and 52,063 GI-NEC cases 18 or older, diagnosed between 2004 and 2019. Histology codes to identify NETs and NECs w...

Background: Targeted therapies for somatostatin receptor-positive NETs have seen significant developments in recent years. Approved and investigational somatostatin analogs for GEP-NETs are changing the treatment landscape for these cancers allowing for better management of difficult-to-treat heterogeneous tumors. To improve competence in applying these advances and to consider patient perspectives in treatment selection, an educational initiative was designed in collaboration...

Background: Patients with neuroendocrine neoplasms (NENs) have chronic symptoms from hormone overproduction, tumor growth and metastasis, and side effects from prolonged treatment. We assessed the feasibility of using a digital health platform to recruit patients with NENs to evaluate symptoms and quality of life.Methods: eNET is a prospective, web-based, cohort study for patients with advanced NENs of any primary site, histologic grade, differentiation,...

Background: In patients with locally advanced pancreatic neuroendocrine tumors (PNET), surgical resection is associated with improved survival. There is a paucity of data whether there is a benefit for multivisceral resection for locally advanced PNET compared to pancreatectomy alone. This study investigated the association of surgical resection on overall survival comparing pancreas specific and multivisceral resection for PNET.Methods: The Surveillance...

Background: There has been increasing interest in the relationship between lifestyle and NET. Results from previously published small observational studies indicate that smoking, alcohol and diabetes may contribute to NET development, but the reported data is conflicting. Additionally, little data is available on diet and physical activity. The aim of the current study is to investigate the association between lifestyle factors and NET development in a large prospective cohort...

Background: Incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEMs) is increasing, but etiology of sporadic, non-familial disease remains obscure. Behavioral risk factors like smoking and alcohol consumption may be associated with GEP-NENs, yet environmental factors potentially associated with GEP-NENs remain unexamined. We regressed age-adjusted incidence rates for GEP-NENs cases in California (CA) on county-level pollution data to determine if an association ...