BES2022 BES 2022 Abstracts (23 abstracts)
Mortality-related risk factors of inpatients with diabetes and COVID-19: a Multicentric Retrospective Study in Belgium
Servais T 1 , Laurent F 2 , Litvine C 3 , De Groote E 4 , Godart V 5 , Repetto E 6 , Ponchon M 7 , Chasseur P 8 , Crenier L 8 , Van Eeckhoudt S 9 , Yango J 10 , Oriot P 11 , Gavriliu M 11 , Rouhard S 12 , Deketelaer B 13 , Bugli C 13 , Belkhir L 14 , Maiter D 1 , Hermans M.P 1 , Yombi JC 14 & Orioli Laura 15
1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; 2Department of Infectiology, Centre Hospitalier Universitaire Ambroise Paré, Mons, Belgium; 3Department of Endocrinology, Centre Hospitalier Universitaire Ambroise Paré, Mons, Belgium ; 4Department of Infectiology, Hôpital de Jolimont, La Louvière, Belgium ; 5Department of Endocrinology-Diabetology, Hôpital de Jolimont, La Louvière, Belgium ; 6Department of Infectiology, Cliniques Saint-Jean, Brussels, Belgium ; 7Department of Endocrinology-Diabetology, Cliniques Saint-Jean, Brussels, Belgium ; 8 Department of Endocrinology, Hôpital Erasme – Cliniques universiraires de Bruxelles, Brussels, Belgium ; 9Department of Internal Medicine and Infectious Diseases, Clinique Saint-Luc Bouge, Namur, Belgium; 10Department of Endocrinology-Diabetology, Clinique Saint-Luc Bouge, Namur, Belgium; 11Department of Diabetology, Centre Hospitalier de Mouscron, Mouscron, Belgium ; 12Department of Endocrinology-Diabetology, Centre Hospitalier Régional de Huy, Huy, Belgium ; 13Support in Methodology and Statistics, UCLouvain, Louvain-La-Neuve, Belgium ; 14Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; 15Pole of Endocrinology, Diabetology and Nutrition, Institute of Clinical and Experimental Research, UCLouvain, Brussels, Belgium
Purpose: We describe the characteristics and prognosis of inpatients with diabetes and coronavirus disease 2019 (COVID-19) in Belgium.
Methods: We conducted a multicentre retrospective study during the first wave of the pandemic, from March 1, 2020 to May 6, 2020. Data on admission of patients with diabetes and hospitalized due to confirmed COVID-19 were collected. COVID-19 diagnosis was based on a positive polymerase chain reaction (PCR) test on nasopharyngeal swab and/or suggestive findings on computed tomography (CT) scan. Survivors were compared to non- survivors in order to identify prognostic risk factors for in-hospital death using multivariate analysis in both the total population and in the subgroup of patients admitted in the intensive care unit (ICU).
Results: The study included 375 patients. The median age was 73 [64-81] years and 93% had type 2 diabetes mellitus (T2DM). Median HbA1c was 7.1 [6.3-8] %. The prevalence of obesity was 49%. The mortality rate was 26.4% (99/375) in the total population and 40% (27/67) in ICU patients. Multivariate analysis identified older age (HR 1.049 [CI 1.03-1.07] per additional year of age, p<0.0001), male sex (HR 2.01 [1.31-3.07], p 0.0013) and C-reactive protein (CRP) elevation on admission (HR 1.00031 [1.0008-1.0054] for each 1 mg/L increase, p 0.0081) as independent risk factors for in-hospital death. Metformin (HR 0.51 [0.34-0.78], p 0.0018) and/or renin-angiotensin-aldosterone system (RAAS) blockers (HR 0.56 [0.36-0.86], p 0.0088) use before admission were independent protective factors.
Main conclusions: In-hospital mortality due to COVID-19 is high in patients with diabetes. We found in a well-phenotyped population that advanced age, male gender and elevated CRP on admission were independent risk factors for death in diabetic patients hospitalized due to COVID-19 in Belgium during the first wave of the pandemic. We also showed that metformin use before admission was associated with a significant reduction of COVID-19-related in- hospital mortality.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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