BES2022 BES 2022 Abstracts (23 abstracts)
Modest changes in sex hormones during early and middle adulthood affect bone mass and size in healthy men. A prospective cohort study
Banica Thiberiu 1,4 , Verroken Charlotte 1,2 , T’Sjoen Guy 2,4 , Goemaere Stefan 1,4 , Zmierczak Hans-Georg 1 , Fiers Tom 3 , Kaufman Jean-Marc 1,2,4 & Lapauw Bruno 1,2,4
1Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium; 2Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.; 3Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium.; 4Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
Bone metabolism in men is in part determined by sex steroid exposure. This is especially clear during puberty and senescence but it remains to be established whether declines in sex steroid levels during young and middle adulthood associate with changes in bone mass and size. This study investigated changes in bone mineral content (BMC), areal and volumetric bone density (aBMD; vBMD) and bone size in relation to sex steroid levels in 999 young adult men (age 24- 46 years) of whom 676 were re-evaluated after a mean period of 12 years. Sex hormone binding globulin (SHBG) levels were measured using immuno-assay, testosterone (T) and estradiol (E2) using LC-MS/MS, free fractions calculated (cFT; cFE2). Areal bone parameters and BMC were measured at the hip and lumbar spine using DXA. Radial and tibial vBMD and bone size were determined using pQCT. Linear mixed models were used for statistical analyses. With aging, we observed decreases in almost all bone mass and density indices whereas changes in bone geometry resulted in larger bones with thinner cortices. These changes in bone mass and size appeared related to sex steroid levels. Specifically, decreases in cFT (but not total T) levels were associated with larger decreases in lumbar spine BMC and especially with geometric changes in cortical bone at the tibia. Similarly, decreases in total E2 and cFE2 were associated with larger decreases in bone mass (all sites) and also with some geometric changes. Also increases in SHBG were independently associated with aging-related changes in bone mass and size in these men. In summary, even small changes in T, E2 and SHBG levels during young and middle adulthood in healthy men are associated with changes in bone mass and size.
Keywords: sex steroids, aging, bone mass, bone geometry, evolution, healthy men
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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