SFEBES2022 Symposia Bone cross-talk with other organs (3 abstracts)
Professor of Medicine, Tufts University School of Medicine, MaineHealth Institute for Research, Scarborough, Maine, 04074, USA
Over the last 15 years there has been a revolution in our understanding of how bone and the marrow communicate with other tissues and organs. It is now clear that adipose tissue, brain, the adrenal, the pancreas, and the marrow itself are targets of skeletal mediators. The means of communication are now starting to be delineated. Neural pathways including the sympathetic system and sensory nerves have been delineated. Hormonal function of skeletal peptides has also been delineated. The three mediators so far identified are osteocalcin, lipocalin-2, and FGF-23. Each of these molecules can have a profound effect on non-skeletal tissue. In addition, stromal cells release peptide factors that can influence neighboring adipocytes, and bone marrow fat cells can target peripheral fat and the pancreas. These mediators will be discussed in detail during the presentation.