SFEBES2022 Poster Presentations Metabolism, Obesity and Diabetes (96 abstracts)
Epidemiology of Diabetes Mellitus in Children in Kazakhstan: Data from Unified National Electronic Health System 2014-2019
Dinara Galiyeva 1 , Dmitriy Syssoyev 1 , Kamilla Mussina 1 , Arnur Gusmanov 1 , Alpamys Issanov 1 , Kuralay Atageldiyeva 1 , Marzhan Rakhimzhanova 2 , Antonio Sarria-Santamera 1 , Dimitri Poddighe 1 & Abduzhappar Gaipov 1
1Nazarbayev University, Nur-Sultan, Kazakhstan; 2University Medical Center, Nur-Sultan, Kazakhstan
Background and aims: We aimed to explore the epidemiology of Diabetes Mellitus (DM) Type 1 and 2 in children aged 0-18 in Kazakhstan based on the aggregated large-scale healthcare data from the Unified National Electronic Healthcare System (UNEHS) in 2014-2019.
Methods: 10,134 incident Type 1 and Type 2 DM pediatric patients were identified through UNEHS. Incidence, period prevalence, and mortality rates per 100,000 population at risk were calculated. The follow-up period was from the initial date of DM diagnosis until death or the end of the follow-up (December 31st, 2019). Cox proportional hazards regression modeling was used to assess the associations between demographic factors with all-cause mortality.
Results: Among 10,134 patients there were 9,310 and 824 children with Type 1 and Type 2 DM, respectively. Median age at diagnosis was 10.0 (interquartile range (IQR) 6.0 – 13.4)) and 13.0 (IQR 8.4 – 15.7) for Type 1 and Type 2 DM, respectively. Retinopathy was the most common complication for both DM types. The incidence rate of DM Type 1 and 2 decreased from 28.1 to 22.0 per 100,000 population and from 3.5 to 2.0, respectively. The period prevalence rate increased from 48.8 to 143.8 per 100,000 population in DM Type 1, and from 4.9 to 12.4 in DM Type 2 patients. Mortality increased twice for DM Type 1 patients but remained consistent for the DM Type 2 patients over the follow-up period. Among DM Type 1 children, female sex, older age, and Kazakh ethnicity were associated with a higher risk of death. Among DM Type 2 patients, only older age was a significant determinant for higher all-cause mortality.
Conclusions: While the incidence of both types of DM in children has been decreasing in Kazakhstan over 2014-2019, the prevalence remains high, with the mortality increasing for DM Type 1 patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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