SFEBES2022 Poster Presentations Reproductive Endocrinology (36 abstracts)
Relationships between adipocyte fatty acid-binding protein with parameters of obesity in women with polycystic ovary syndrome
Aleksandra Polak , Agnieszka Łebkowska , Anna Krentowska , Angelika Buczyńska , Adam Krętowski , Irina Kowalska & Agnieszka Adamska
Medical University of Białystok, Białystok, Poland
Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.
Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and the amount of adipose tissue assessed during bioelectrical impedance in women with PCOS.
Materials and Methods: We examined 133 patients: 66 women diagnosed with PCOS by the Rotterdam criteria and 67 healthy controls, matched by the body mass index. Serum concentrations of A-FABP, total testosterone were measured and free androgen index (FAI) was calculated. Body composition analysis was conducted using bioelectrical impedance analysis.
Results: In the PCOS group, the serum concentrations of A-FABP, total testosterone and FAI were significantly higher in comparison to the control group (all P<0.05; respectively). We found association between FABP-A and WHR (r=0.26, P=0.04) and percentage of adipose tissue (r=0.33, P=0.01) assessed by bioelectrical impedance in women with PCOS, whereas this relationship have not been found in the control group ((r=-0.06, P=0.64), (r=0.16, P=0.22); respectively).
Conclusion: Our results indicate that A-FABP is an adipokine that may be connected with abdominal obesity in PCOS patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more