Endocrine Abstracts

Aim: We explored the mechanistic interactions and potential therapeutic benefits of curcumin and quercetin co-administration with a specific focus on Glycogen synthase kinase 3 GSK-3 activity.

Methods: We hypothesize that excess GSK-3 accumulation in the substantia nigra is driven by oxidative stress and aim to test the effects of these compounds on the localization and activity of GSK-3 in the well-established model organism Drosophila melanogaster. We probed the dopaminergic neutrons characterization via Tyrosine Hydroxylase Confocal microscopy.

Results: The antioxidant properties of curcumin with quercetin mediated an anti-inflammatory response, ameliorating oxidative stress in the brain. The co-administration of both compounds as well rescue the Dopaminergic neurons in the brain of the shaggy fly.

Conclusion: The co-administration of curcumin and quercetin were able to reduce the loss of function of the nervous system typical of GSK 3 shaggy strain, by reducing the over expression of GSK 3 beta.