SFEBES2022 Poster Presentations Thyroid (41 abstracts)
The potential interaction between medical treatment and radioiodine treatment success: a systematic review
Riazul Zannat 1 , Jonathan Lee 2 , Jameel Muzaffar 3 , Martin L. Read 1 , Katie Brookes 1 , Neil Sharma 2,4 , Kristien Boelaert 5 , Christopher J. McCabe 1 & Hannah T. Nieto 1
1Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom; 2University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 3Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; 4Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; 5Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom
Introduction: Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic option in the treatment of hyperthyroidism. Previous work suggests that antithyroid drugs hinder the efficacy of RAI therapy in patients. However, the effects of other background medications on RAI treatment efficacy have not been evaluated. Therefore, we performed a systematic review and metanalysis investigating the potential off-target effects of medication on RAI therapy in patients with thyroid cancer and hyperthyroidism.
Methods: Systematic review and meta-analysis according to the 2020 PRISMA guidelines. Databases searched: MEDLINE, EMBASE and Cochrane Library for studies published between 2001 and 2021.
Results: Sixty-nine unique studies were identified. After screening, 17 studies with 3313 participants were included. One study investigated thyroid cancer, with the rest targeted to hyperthyroidism. The majority of studies evaluated the effects of antithyroid drugs; the other drugs studied included lithium, prednisone and glycididazole sodium. Antithyroid drugs were associated with negative impacts on post-RAI outcomes (n=5 studies, RR=0.81, P=0.02). However, meta-analysis found moderate heterogeneity between studies (I2 = 51 %, τ2 = 0.0199, P=0.08). Interestingly, lithium (n=3 studies), prednisone (n=study) and glycididazole (n=1 study) appeared to have positive impacts on post-RAI outcomes upon qualitative analysis.
Conclusion: Our review reinforces previous work regarding the effects of antithyroid drugs on RAI outcomes. However, the lack of standardisation between studies supports further randomised control trials with uniform standards.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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