SFEBES2022 Poster Presentations Neuroendocrinology and Pituitary (72 abstracts)
Imaging surveillance of completely resected gastroenteropancreatic neuroendocrine tumors is associated with high levels of radiation exposure
Jordan Ianuzzi 1 , Caitlin Yeo 1 , Vicky Parkins 1 , Janice Pasieka 1 , Dean Ruether 1 , Denise Chan 1 , Zaina Albalawi 1 , Errol Stewart 2 & Kirstie Lithgow 1
1Cumming School of Medicine, Calgary, Canada; 2Alberta Health Services, Calgary, Canada
Background & Aims: Neuroendocrine tumours (NET) are a heterogenous group of neoplasms that secrete peptides and neuroamines. For potentially malignant gastroenteropancreatic (GEP) NET, surgical resection represents the only curative option. Ten-year imaging surveillance programs using cross sectional imaging are recommended due to long time-to-recurrence following resection. We performed a retrospective chart review to evaluate radiation exposure associated with surveillance of completely resected GEP NET and characterize local practice patterns.
Methods: We reviewed records from patients diagnosed with well-differentiated GEP NET from January 2005 to July 2020. Eligible cases were identified by a data analyst and manually screened for eligibility. Location of primary, modality of surveillance imaging, and duration of follow-up were collected [JC1]. Dosimetry data was collected to calculate total effective dose and mean effective dose per year.
Results: Sixty-two cases met inclusion criteria with 422 surveillance scans performed. Cross sectional imaging was used in 82% and functional imaging was used in 18% of scans. Mean number of surveillance scans per year was 1.25 (0.42 – 3). Mean total effective dose was 59.37mSv (SD 46.20; 0 to 203.62mSv) while mean total effective dose per year was 11.19mSv (SD 9.55; 0 to 45.25mSv). Over the recommended 10 years of surveillance, the estimated total effective dose was 112mSv. Age at diagnosis and location of primary were not significant predictors of effective dose per year.
Conclusions: Imaging surveillance of completely resected GEP NET results in cumulative radiation doses in the range associated with secondary malignancy development. Strategies to minimize radiation exposure in long term surveillance should be considered in future guideline development.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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