SFEBES2022 Poster Presentations Metabolism, Obesity and Diabetes (96 abstracts)
Examining the relationship between gestational diabetes, maternal pre-pregnancy body mass index (BMI) and large for gestation age neonates by ethnicity
Pei Chia Eng , Chiara Veidi , Edward Mullins , Jayne Terry , Bryony Jones , Anne Dornhorst , Chukwuma Uduku , Lynne Sykes , Christina Yu , Stephen Robinson & Rochan Agha-Jaffar
Imperial College London, London, United Kingdom
Objective: To determine if the impact of pre-pregnancy body mass index (BMI), fasting glucose levels and post load glucose levels on large for gestational age neonates varies with ethnicity.
Data sources: Electronic health records of all eligible pregnant women in an inner city service. Study designRetrospective analysis of pregnant women at risk of developing gestational diabetes mellitus (2016-2019) of. Population or sampleEligible pregnant women. Synthesis methodMaternal and fetal characteristics were compared across five ethnic groups: White, Black African-Caribbean, South Asian, Mixed/Other Asian and other/Unknown. A customized birth centile calculator was used to determine prevalence of LGA in each ethnic group by category of maternal BMI, fasting glucose and 120-minutes plasma glucose. Association between fetal macrosomia and maternal BMI, fasting and 120-minutes plasma glucose were assessed across ethnic groups using multilinear regression analyses (with White ethnicity as the reference group).
Results: Among the 16788 participants, 36.8% were women of white origin, 21.8% Black African Caribbean, 8.8%South Asian, 20.9% Mixed origin and 12.1% originated from other ethnic groups. Mothers of Black and African Caribbean, South Asian and Mixed origin delivered a higher proportion of LGA neonates at low pre pregnancy maternal BMI categories (< 18.5) and high BMI categories (only for black).
Conclusions: Ethnicity influences percentage of large for gestational age neonates. Glucose threshold to define LGA risk differs in each ethnic groups. Ethnic specific glucose threshold to define LGA could be indicated.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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