Endocrine Abstracts

Introduction: Pheochromocytomas and paragangliomas(PPGLs) are catecholamine-secreting tumors. Catecholamine excess contributes to bone resorption and secondary osteoporosis. PPGLs are treated surgically but limited data exists on the subsequent effect on bone status.

Aim: To evaluate bone metabolism(BM) and bone mass density(BMD) before and after successful surgery of PPGLs.

Methods: A retrospective study on (BM) of (PPGLs) patients in comparison with non-functional adrenal tumors(NFAT) patients during the period(1991-2021) was conducted. Patients with malignancies, conditions and medications affecting (BM) and postmenopausal women were excluded. 63 (PPGLs) and 52 (NFAT) patients were included. They were evaluated at diagnosis and 1 year after (PPGLs) surgical resection or (NFAT) diagnosis.

Results: Both groups had comparable age(years)(50±14vs48±9,P=0.26), sex (females(%))(47.6vs46.2,P=0.44) and BMI(kg/m ²)(26.3±4vs24.8±4, P=0.05). At diagnosis (PPGLs) patients had higher mean P1NP(μg/l)(46±12vs39±15, P=0.01) and b-crosslaps(pg/ml) (0.56±0.21vs0.44±0.2, P=0.006). BMD(g/cm ²) and T-Score in Femoral Neck(FN)(0.75±0.1vs0.81±0.1, P=0.02 and -1.11±0.7vs-0.79±0.7,P=0.039) and BMD in Lumbar Spine(LS)(0.84±0.1vs0.88±0.1,P=0.043) were significantly lower compared to (NFAT) group. 1 year after surgery, P1NP had significantly decreased (38±13vs46 ±11.5,P=0.0008) and were comparable in the 2 groups (38±13vs40±13,P=0.51) while b-crosslaps were significantly lower in (PPGLs) patients (0.4±0.2vs0.5±0.2,P=0.004). Non-significant changes were noticed for BMD and T-Score in (FN)(0.77±0.1vs0.75±0.1,P=0.29), (-0.94±0.8vs-1.11±0.8, P=0.26) and (LS)(0.86±0.1vs0.84±0.1,P=0.28), (-0.83±0.8vs-0.98±0.8, P=0.33) of (PPGLs) patients. (PPGLs) patients did not differ any more for BMD and T-Score from (NFAT) patients in the (FN)(0.77±0.1vs0.78±0.2, P=0.79),(-0.94±0.8vs-0.89±0.8,P=0.72) and the (LS)(0.86±0.1vs0.87±0.1, P=0.73),(-0.83±0.8 vs -0.77±0.8,P=0.68).

Conclusions: (PPGLs) are associated with deterioration of (BM) and BMD. 1-year after surgical treatment (BM) markers improve while BMD remains unaltered in the cortical and trabecular bone.