Endocrine Abstracts

Contents

• Plenary Lectures
• • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Novel approaches for cushing’s medical management: Guidelines to clinical practice

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  • Society for Endocrinology Starling Medal Lecture
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  • Society for Endocrinology Dale Medal Lecture
  • • Mining the genome for translational gold

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  • Society for Endocrinology Jubilee Medal Lecture
  • • The MRAP files: Supporting the blob

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  • Society for Endocrinology International Medal Lecture
  • • Insights into the Cell and Molecular Control Pathways that Regulate Cancers in the Skeleton

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • The impact of adipocytes and adipose tissue on systemic metabolism

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  • British Thyroid Association Pitt-Rivers Lecture
  • • TED/GO from bench to bedside

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  • Society for Endocrinology European Medal Lecture
  • • Skeletal cell metabolism: more than bioenergetics and bystander effect

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  • Society for Endocrinology Medal Lecture
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  • Clinical Endocrinology Trust Lecture
  • • Why don't we cure all patients with Graves' disease?

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• Presidential Lecture
• • Antibodies and antibody mimics as pharmaceutical drugs
  • • Antibodies and antibody mimics as pharmaceutical drugs

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• Debate
• • Motion: This House believes that Vitamin D supplementation should be a high public health priority
  • • This house believes that Vitamin D supplementation should be a high public health priority. For the motion

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    • Abstract unavailable

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• Society for Endocrinology Journal Awards
• • Society for Endocrinology Journal Award – Journal of Endocrinology
  • • Early or delayed time restricted feeding prevents metabolic impact of obesity in mice

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  • Society for Endocrinology Journal Award – Journal of Molecular Endocrinology
  • • Diversification of mineralocorticoid receptor genes in a subterranean rodent, the naked mole-rat

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  • Society for Endocrinology Journal Award – Endocrine-Related Cancer
  • • Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

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  • Society for Endocrinology Journal Award – Endocrine Connections
  • • Phaeochromocytomas overexpress insulin transcript and produce insulin

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  • Society for Endocrinology Journal Award – Clinical Endocrinology
  • • Cardiac phenotype in familial partial lipodystrophy

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• Awards and Prizes
• • Teaching Achievement Award
  • • SIMBA and CoMICs - developing evidence-based, minimal cost, and sustainable medical education programmes

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  • Outstanding Clinical Practitioner Award
  • • What Endocrinology has taught and given me

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  • Nikki Kieffer Medal
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• Early Career and Plenary Orals
• • Early Career Prize Lecture Basic Science
  • • The diverse and distinct roles of adipose tissue on metabolic heath

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  • Early Career Prize Lecture Clinical
  • • Central adiposity raises serum calcium concentrations and increases risk of kidney stone disease

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  • Clinical Endocrinology Trust Best Abstract Clinical
  • • Individuals on levothyroxine have higher HADS anxiety and depression scores than the general population and this is exacerbated by the Thr92Ala substitution in DIO2

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  • Clinical Endocrinology Trust Best Abstract Basic
  • • Characterising the G-protein signalling mechanisms activated by short chain fatty acids in human enteroendocrine cells which mediate production and release of the anorectic gut hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1)

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• Symposia
• • Bone cross-talk with other organs
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    • Bone cross talk with other organs

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    • Skeletal fragility and diabetes

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  • Drugable hormones and their receptors: past, present and future. Are we running out of targets? Are there more hormones to find?
  • • Therapeutic potential of an old friend - the dichotomy of amylin in physiology and pathophysiology

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    • Can we drug receptors for microbially-produced metabolic hormones?

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  • Therapy extension and repurposing in endocrine cancer
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  • Old hormones, new tricks: new approaches for treating reproductive diseases
  • • Size matters. Small molecule targeting of gonadotrophin hormone receptors

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  • New approaches to diagnosing and treating thyroid cancer
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    • Are we overtreating low-risk thyroid cancer?

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    • Novel target therapies for advanced thyroid cancers

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  • Novel therapeutics and diagnostics in adrenal disease
  • • Stem cell therapy in adrenal insufficiency

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    • New applications of steroid metabolomics to adrenal tumours

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• What is New?
• • Section
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    • What is new (Clinical)

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• Clinical Management Workshops
• • Endocrine disease in pregnancy: pitfalls in testing and challenges in management; before, during and after
  • • Diagnosis and management of adrenal insufficiency in pregnancy

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    • Hyperthyroidism

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  • State of the art in identifying and managing aggressive pituitary disease
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    • Technological advances in surgical therapy for pituitary adenoma

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    • Non-surgical therapies for aggressive pituitary tumours

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• Basic Physiology Workshops
• • New techniques and approaches
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    • Modelling exercise in cells, mice and man - the importance of timing

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    • Female endocrine adaptation to arduous training

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  • New advances in neuroendocrinology
  • • How does the brain know what you've eaten?

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    • New methods to investigate the GnRH pulse generator

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    • How does the pituitary decode GnRH signals?

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• How Do I. . .? Sessions
• • How do I...? 1
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    • How do I diagnose and manage post-bariatric hypoglycaemia?

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    • How do answer the common difficult questions from patients with hypothyroidism?

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    • How do I use TRAb measurements to guide management in my patient with Graves' disease (GD)

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    • How do I monitor a patient on mitotane?

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    • How to manage normocalcaemic hyperparathyroidism

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  • How do I...? 2
  • • Outstanding clinical practioner award: how do i wean patients who have had pituitary or adrenal cushings syndrome off glucocorticoids once they are in remission?

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    • Outstanding clinical practioner award: how do i rationalise withdrawal of liothyronine (T3) in a symptomatic tired, depressed and vulnerable patient with chronic fatigue syndrome or long COVID who may or may not have hypothyroidism?

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    • How do I choose an oral contraceptive for my patient with PCOS?

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    • How do I manage a patent with menopausal symptoms in whom HRT is contra-indicated?

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    • How do I investigate hypophosphataemia?

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• Meet the Expert Sessions
• • Nurse
  • • Interventions for preventing adrenal crisis - behavioural insights

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    • Endocrine complications after childhood cancer

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  • Adrenal and Cardiovascular
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  • Thyroid
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  • Endocrine Cancer and Late Effects
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    • How to identify brittle bones after childhood cancer therapy

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  • Bone and Calcium
  • • Imaging of bone for endocrinologists; from DXA onwards

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  • Reproductive and Neuroendocrinology
  • • How to study sex: new approaches for investigating sex determination pathways

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  • Metabolism, Obesity and Diabetes
  • • Metabolic lessons from patients undergoing sex reassignment

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• Clinical Skills
• • Radiology for the endocrinologist
  • • Trials and tribulations of targeting 11[beta]-HSD1

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• Basic Skills
• • How to go from bench to bedside
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• Early Careers Session
• • Research Pathways Outside of Academia
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    • An introduction to working in the world of scientific storytelling for the pharmaceutical, biotechnology, medical device and consumer health industries

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• Career Perspectives Session
• • Section
  • • Biological clocks and the endocrine system

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    • Another insulin! what’s not to like?

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    • What talks to brown fat?

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• Nurse Session
• • Neuroendocrine tumours
  • • The management of neuroendocrine tumours

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    • Patient perspective of multiple endocrine neoplasia syndromes

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  • Hot topics in endocrinology
  • • Endocrine effects of checkpoint inhibitor immunotherapy

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    • Menopause; it’s not just a hot flush

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  • Craniopharyngiomas and new investigations
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• Defining The Future of Endocrinology
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• Cutting Edge Session
• • Endocrinology in a Warming Dirty World
  • • Endocrine disrupting chemicals: new knowledge of health effects and policy implications

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    • Environmental endocrine disruption of brain and behavior across generations

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• Endocrine Network Sessions
• • Metabolism, Obesity and Diabetes
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  • Endocrine Cancer
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  • Neuroendocrinology
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  • Thyroid
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  • Adrenal and Cardiovascular
  • • [ldquo]Management of iatrogenic adrenal insufficiency - tip of the iceberg[rdquo]

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  • Bone and Calcium
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  • Endocrine Consequences of Living With and Beyond Cancer
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    • Incidence of endocrine deficits after management of brain tumours

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  • Reproductive Endocrinology and Biology
  • • Clinical Management of Menopause

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  • Endocrine Teaching Network
  • • The biomedical kitchen: Demystifying the laboratory for students

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• Oral Communications
• • Bone and Calcium
  • • Evaluation of efficacy and safety of a novel gene therapy drug (ARU-2801) for hypophosphatasia in non-human primates

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    • Hypercalcaemic mice harbouring a germline ablation of G-protein subunit alpha-11 have anaemia that is corrected by treatment with erythropoietin

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    • X-linked osteoporosis caused by a novel c.892-2A>G plastin 3 (PLS3) splice variant

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    • Measurements of circulating conjugated and unconjugated vitamin D metabolites by enzyme hydrolysis combined with liquid chromatography mass spectrometry

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    • Can pre-operative treatment with intravenous bisphosphonates or cinacalcet have an effect on intra-operative parathyroid hormone measurements?

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    • The AXT914 calcilytic compound increases plasma calcium and PTH in a mouse model for autosomal dominant hypocalcaemia type 1 (ADH1)

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  • Endocrine Cancer and Late Effects
  • • Generation of conditional MEN1 knockout human induced pluripotent stem cells (iPSCs) provide a genetically-tractable disease model to investigate cell-type specific gene function

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    • Promotion of thyroid cancer cell migration and invasion by the proto-oncogene PBF is mediated by FGD1 and N-WASP

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    • Identification of five prolactin receptor variants with diverse effects on receptor signalling

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    • Delta-like non-canonical Notch ligand 1 (DLK1) - a novel biomarker in adrenocortical carcinoma

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    • Plasma metabolites correlate with disease in sdhx deficient cancer syndromes

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    • Repurposing disulfiram as a therapeutic agent to enhance sodium iodide symporter activity in radioiodide therapy

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  • Reproductive and Neuroendocrinology
  • • Depot somatostatin receptor ligand therapy reverses tissue thyrotoxicosis in thyrotropinomas and aids microadenoma localization via ¹¹C-Methionine PET

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    • BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

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    • Long-term efficacy and safety of oral, once-daily paltusotine treatment in acromegaly: Two-year interim results from the ACROBAT Advance study

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    • Maternally derived pancreatic extracellular vesicle miR-375 contributes to large-for-gestational-age infants in pregnancies complicated by gestational diabetes

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    • Radiomics as a tool for risk stratification of non-functioning pituitary adenomas following primary surgery

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    • Kisspeptin enhances sexual and attraction brain processing in women with low sexual desire

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  • Adrenal and Cardiovascular
  • • Introducing technology to improve patient safety in adrenal insufficiency: a proof-of-concept delivery of a new smartphone app in steroid-dependent patients

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    • Generation of novel tools for the study and development of targeted therapeutic approaches for pheochromocytoma and paraganglioma

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    • Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19

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    • Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

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    • Comparison of prednisolone and modified-release hydrocortisone capsules in the treatment of congenital adrenal hyperplasia: dose and disease control

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    • Glucocorticoid excess elevates metabolic rate via a 11[beta]-HSD1 dependent mechanism in C57BL/6J mice

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  • Metabolism, Obesity and Diabetes
  • • Human brown adipose tissue demonstrates substantial choline uptake for incorporation into phosphatidylcholines

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    • 7[alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is a novel AKR1D1 substrate driving metabolic dysfunction and hepatocellular cancer risk in patients with non-alcoholic fatty liver disease (NAFLD)

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    • Normothermic machine liver perfusion as a tool to study human androgen metabolism

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    • New avenues for vertical sleeve gastrectomy-induced diabetes remission mechanisms: kidney-adipose tissue axis

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    • Upregulation of hepatic de novo lipogenesis dissociates from changes in liver fat content and insulin sensitivity in healthy humans

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    • Labelling and characterisation of somatostatin secreting D-Cells in primary human duodenal organoids culture

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  • Thyroid
  • • Single cell analysis for the human developing thyroid uncovers thyrocytes heterogeneity

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    • Enhancing radioiodide uptake by addressing the mechanism of sodium/iodide symporter (NIS) endocytosis

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    • Long-Term effectiveness of ethanol ablation in controlling selected postoperative neck nodal metastases in fourteen patients presenting with ATA pediatric intermediate or high-risk papillary thyroid carcinoma

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    • Towards an automated app-based dose prescription of carbimazole for hyperthyroidism patients

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    • Thyroid hormones promote mammary metabolic pathways required for milk synthesis: Relevance to the onset of lactation

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    • Can systemic cytokines predict relapse of graves' disease?

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• Oral Poster Presentations
• • Thyroid
  • • The 'real-world' outcomes of immunosuppression for Graves' orbitopathy (GO) in a single centre multi-ethnic cohort

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    • Long-term mortality and cardiometabolic effects of treatment for hyperthyroidism: EGRET study

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    • Levothyroxine absorption test: a therapeutic strategy for improving medication adherence

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    • The role of oxidative stress in differentiated thyroid cancer risk stratification

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  • Adrenal and Cardiovascular
  • • Novel radiolabeled ligand, Para-chloro-2-[¹⁸F]fluoroethyletomidate (CETO) compared to [¹¹C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)

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    • Can serum and urine Fludrocortisone measurements guide mineralocorticoid replacement therapy in primary adrenal insufficiency?

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    • Complete clinical cure of primary aldosteronism (PA) is predictable and sustained for at least two years

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    • Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice

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  • Reproductive and Neuroendocrinology
  • • Kisspeptin enhances penile tumescence and sexual brain processing in men with low sexual desire

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    • Identification of differentially activated pathways in recurrent non-functioning pituitary tumours using quantitative proteomics and bioinformatics analysis

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    • Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3/PROKR1 immunoreactivity

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    • Identification and characterisation of novel follicle-stimulating hormone receptor antagonists

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  • Metabolism, Obesity and Diabetes
  • • The effects of a tripeptide hormonal infusion on sweet taste function and eating behaviour

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    • Differential effects of L- and D-lactate on HCAR1 signalling

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    • miR-10b is an essential regulator of adipogenesis

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    • iPSC-derived hepatocytes as a novel tool for glycogen storage disease 1A (GSD1A) modelling and drug screening

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  • Bone and Calcium
  • • 3' UTR structural elements are associated with CYP24A1-mediated abnormal calcium handling

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    • Hyperparathyroidism jaw tumour syndrome due to a novel familial CDC73 germline mutation

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    • Lower bone mineral density is associated with primary hyperparathyroidism patients with abnormal vitamin D metabolite ratio (VMR): A case-control study

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    • Prospective clinical trial of a novel, reusable, pocket size Point of Care device to measure ionized calcium in venous and capillary blood and saliva

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  • Endocrine Cancer and Late Effects
  • • Post-Transcriptional regulation of wild-type and variant androgen receptors during prostate cancer progression

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    • Investigating the utility of microRNA signatures as a tumour biomarker in patients with succinate dehydrogenase deficient phaeochromocytoma, paraganglioma and GIST

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    • Knockout mouse embryonic fibroblasts reveal a physiological role for the proto-oncogene PBF in cell adhesion and motility

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    • Endocrinopathies in cancer patients receiving immune checkpoint inhibitors are associated with an improved overall survival

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• Featured Clinical Case Posters
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• Poster Presentations
• • Adrenal and Cardiovascular
  • • Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison’s disease cohort

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    • Radiological and biochemical assessment of adrenal incidentalomas need improving to prevent unnecessary follow up

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    • Identification and characterization of a receptor for N-terminal pro-opiomelanocortin peptide

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    • Bone health optimisation and patient education in adult congenital adrenal hyperplasia patients

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    • Evaluation of fracture risk in patients with mild autonomous cortisol secretion and adrenal incidentaloma

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    • Adrenalectomy for unilateral primary aldosteronism improves quality of life: prospective analyses in the MATCH trial

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    • Gender-Related Analytical Bias in Biochemistry - Under-Recovery in a Serum Cortisol Immunoassay

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    • Inflammation-Based Scores as Predictors of Treatment Response in Advanced Adrenocortical Carcinoma

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    • Practices in perioperative management of patients with pheochromocytoma and paraganglioma: a Scoping Review

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    • Development of novel immunoassays for pro-opiomelanocortin (POMC)-derived peptides as surrogate markers of adrenocorticotrophin levels for use in the diagnosis of Cushing’s syndrome

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    • Phaeochromocytomas Most Commonly Present As Adrenal Incidentalomas - A Large Tertiary Centre Experience

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    • Counselling for adrenal insufficiency for patients on long term steroids amongst physicians and patients

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    • Factors which contribute to LDL-C target attainment in familial hypercholesterolaemia

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    • Involvement of the adrenal gland in post-bariatric surgery Type 2 Diabetes remission

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    • Can we use swabs to collect samples for salivary androgen analysis?

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    • Adrenal insufficiency caused by herbal remedies - a case presentation

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    • Adrenal reserve and glucocorticoid requirements post unilateral adrenalectomy for primary aldosteronism

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    • An Audit of Adrenal Vein Sampling in a large teaching hospital in Leeds

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    • Cortisol/cortisone measurement in sweat samples

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    • Adrenal function in patients with extrapulmonary tuberculosis using serum and salivary cortisol

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    • Hyperaldosteronism caused by sertraline

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    • Endocrine Complications and Metabolic Risk in Sleep Apnoea

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    • A Case of Pheochromocytoma with Haematuria

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    • Coincidence of Primary Adrenocortical Carcinoma and Melanoma: Three Case Reports

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    • Primary adrenal lymphoma as the culprit of fever of unknown origin and adrenal insufficiency

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    • Sulfasalazine as a cause of false positive elevation of normetanephrine in patients with adrenal mass - A diagnostic challenge

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    • Utility of point of care ultrasound (POCUS) as an adjunct investigation for guiding fluid management in severe hyponatraemia

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    • Preliminary data from FABULAS: a Feasibility study of RadioFrequency endoscopic ABlation, with ULtrasound guidance, as a non-surgical, Adrenal Sparing treatment for aldosterone producing adenomas

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    • HLA-DRB1*0404 is associated with the deletion of the 21-hydroxylase pseudogene in AAD patients

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    • Glucocorticoid Excess Disrupts the NAD+ Metabolome Within Skeletal Muscle in Male and Female C57BL/6J Mice

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    • Whole genome sequencing and Sanger sequencing to identify novel mutations in adrenal tumours from cats with primary hyperaldosteronism

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    • Depleting NAD+ pools specifically in the endoplasmic reticulum lumen impairs 11[beta]-hydroxysteroid dehydrogenase activity

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    • Salivary dexamethasone and 11-dehydrodexamethasone analysis post overnight dexamethasone suppression test

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    • An audit of the clinical utility of urine steroid profiling for endocrine disorder diagnosis in a routine clinical laboratory in 2021

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    • Mapping the chromatin-associated-lncRNAs and their enhancer regions between lymphatic and endothelial cells

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    • Prednisolone replacement therapy in Adrenal Insufficiency: Defining target ranges and timing for optimum Prednisolone level sampling

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    • 5mg of Prednisolone results in over-replacement in individuals with Adrenal Insufficiency

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    • Validating the cholesterol-year-score as a predictor of major cardiovascular events in familial hypercholesterolaemia

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    • Review of clinical and biochemical characteristics, perioperative management and surgical outcomes in patients undergoing surgery for primary hyperaldosteronism (PHA) at The University Hospital Southampton NHSFT (UHS)

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    • Oral itraconazole augments iatrogenic Cushing’s syndrome and adrenal insufficiency after medication withdrawal

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    • Review of multidisciplinary perioperative management of functioning and non-functioning adrenal lesions at The University Hospital Southampton NHSFT (UHS)

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    • The Value of Baseline Cortisol in Predicting a Preserved Cortisol Response to Synacthen

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    • Inclisiran for the treatment of hypercholesterolemia in clinical settings

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    • Adrenal Incidentaloma Service in a DGH; Role of an endocrine pharmacist

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    • Audit of adrenal lesions incidentally found on imaging in a London hospital: What is the clinical outcome?

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    • Myriad Complications of Cushing’s syndrome

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    • Silent clinical picture at diagnosis in incidentally discovered large pheochromocytomas

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    • Adrenal adenomas: an atypical case

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    • Detection rate and management of adrenal incidentalomas at Gozo General Hospital (GGH)

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    • Neonatal salt wasting: A rare case of X-linked adrenal hypoplasia congenita

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    • Type 1 Diabetes in remission following adrenalectomy for sporadic phaeochromocytoma

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    • A case of 17-alpha-hydroxylase deficiency congenital adrenal hyperplasia presenting with delayed puberty

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    • Mapping corticosteroids in mouse kidney following changes in dietary salt intake using mass spectrometry imaging

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    • Screening for adrenal insufficiency using home waking salivary cortisone is accurate and lowers NHS costs

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    • Using mass spectrometry imaging to study the lipidome of atherosclerotic plaques

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    • Feasibility of primary aldosteronism screening in primary care - prevalence and concordance with secondary care assessment

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    • The importance of questioning the ACTH result in Cushing’s and potential need for a two-site assay

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    • Prednisone is 100% converted to Prednisolone by first pass metabolism

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    • Prolonged adrenal suppression does not always need additional glucocorticoid therapy

      ea0086p304
    • The utility value of genetic testing in endocrine syndromes

      ea0086p305
    • Appropriateness of aldosterone renin ratio (ARR) testing: A retrospective multicentre audit

      ea0086p306
    • Pheochromocytoma in patient with Neurofibromatosis 1 (NF1) radiologically mimicking Neurofibroma

      ea0086p307
    • Severe Tiredness in patient treated with itraconazole in Aspergilloma and Type 1 Diabetes

      ea0086p308
    • Case of herbal tea causing severe hypokalaemia and hypertension

      ea0086p309
    • Pheochromocytoma masquerading as acute coronary syndrome

      ea0086p310
  • Bone and Calcium
  • • Is finger prick blood collection using Mitra® volumetric absorptive microsampling (VAMS) device a viable alternative to venous for testosterone, cortisol, 25 hydroxyvitamin D and bone resorption marker [beta]-CTX measurements?

      ea0086p28
    • The dangers of ward-based treatment of hypocalcaemia with intravenous calcium replacement

      ea0086p29
    • Recognition and acute management of parathyroid crisis; early localization and surgery

      ea0086p30
    • COVID-19 Induced Hypoparathyroidism

      ea0086p31
    • Medical optimisation and multidisciplinary approach to management of hyperparathyroid crisis in an elderly patient

      ea0086p32
    • Is Vitamin D Toxicity inevitable without tighter regulation of over the counter sales?

      ea0086p33
    • Important learning lessons from a rare case of hypoparathyroidism

      ea0086p34
    • The Accuracy of Imaging test (USS and Sesta MiBi scan) for pre-operative localization in a patient with Primary Hyperparathyroidism who underwent parathyroidectomy

      ea0086p35
    • Milk-alkali syndrome presenting as severe hypercalcemia in pregnancy

      ea0086p36
    • The management of autosomal dominant hypoparathyroidism with CaSR mutation in pregnancy and breastfeeding

      ea0086p37
    • Humoral Hypercalcaemia in pregnancy

      ea0086p38
    • An unusual case of severe hypercalcaemia due to treatment resistant Graves' disease

      ea0086p39
    • Yet another case of hypercalcaemia!

      ea0086p40
    • Advanced Software to Diagnose the Early onset of Osteoporosis

      ea0086p41
    • Bone metabolism and bone mass density following successful treatment of catecholamine secreting tumors

      ea0086p178
    • Primary Hyperparathyroidism: Correlation between Image Findings and Histology Data

      ea0086p179
    • Parathyromatosis

      ea0086p180
    • A novel mutation on GNA11 as a cause of familial hypocalciuric hypercalcaemia

      ea0086p181
    • A novel mutation on MEN1 as a cause of familial primary hyperparathyroidism

      ea0086p182
    • Management of Cystic Fibrosis-related bone disease with bisphosphonates: An audit in a tertiary care hospital in the UK

      ea0086p183
    • Post-Operative Bone Health Assessment and Optimisation Remains Suboptimal in Primary Hyperparathyroidism

      ea0086p184
    • Finding the Culprit: A Rare Case of Oncogenic Osteomalacia

      ea0086p185
    • Primary Hyperparathyroidism Audit: Does routine Ultrasound Kidneys add value?

      ea0086p186
    • High Parathyroid hormone- Think out of the box!

      ea0086p187
    • Severe symptomatic and treatment resistant hypercalcaemia caused by a parathyroid adenoma

      ea0086p188
    • Denosumab induced recurrent, prolonged and life threatening hypocalcaemia

      ea0086p189
    • Analysis of receipt of bone protection prescribed post hip fracture in patients presenting for DXA

      ea0086p190
    • A case of Familial hypocalciuric hypercalcemia with markedly elevated serum calcium

      ea0086p191
    • An initial disturbing finding in the follow-up of medullary thyroid carcinoma after surgery- in the Vth laterocervical compartment may represent a positive course of the disease. Case Report

      ea0086p192
    • Comparison of newly derived and existing formulae for the estimation of biologically active calcium

      ea0086p311
    • Hypercalcaemia in Renal Transplant Patients

      ea0086p312
    • Bone Turnover Markers for Assessment of Anti-Resorptive Effect in Clinical Practice: A Good Idea Meets the Problem of Measurement Uncertainty

      ea0086p313
    • Appropriateness of parathyroid imaging in patients with primary hyperparathyroidism

      ea0086p314
    • Comparison of Preoperative Imaging Modalities in Primary Hyperparathyroidism

      ea0086p315
    • Severe hypercalcaemia with short QT interval due to vitamin D intoxication secondary to unsupervised exogenous vitamin D administration

      ea0086p316
    • A rare case of asymptomatic hyperplastic ectopic parathyroid tissue within the thymus: what are the clinical implications?

      ea0086p317
    • Hypocalcaemia Driven by Proton Pump Inhibitors: An Increasing but Poorly Recognised Problem

      ea0086p318
    • Denosumab for refractory hypercalcemia due to primary hyperparathyroidism in patient with COVID-19

      ea0086p319
    • Primary Hyperparathyroidism in a patient with Alport syndrome

      ea0086p320
    • Unusual Association of Hypercalcemia in a Patient with Coeliac Disease

      ea0086p321
  • Endocrine Cancer and Late Effects
  • • Hydroxymethylation is dysregulated in pancreatic neuroendocrine tumours and associated with aberrant DNA methylation

      ea0086p42
    • Gene-specific application of computational prediction tools aids the classification of rare missense variants in the diagnosis of hereditary endocrine tumour syndromes

      ea0086p43
    • Abstract unavailable

      ea0086p44
    • Emergency Ambulatory Outpatient Management of Immune Checkpoint Inhibitor-mediated Hypocortisolaeamia

      ea0086p45
    • Neuroendocrine Tumour (NET) patient satisfaction in the COVID-19 recovery period: A patient survey from a European Neuroendocrine Tumour Centre of Excellence

      ea0086p46
    • A Rare Occurrence of Phaeochromocytoma in an Adult with Previously Diagnosed Wilms Tumour - Case Report

      ea0086p47
    • Clomiphene Citrate induced changes in the Estrogen and Estrogen receptors in the ovary of female Sprague-Dawley rats

      ea0086p193
    • The incidence and clinical significance of metabolically active brown adipose tissue in patients with pheochromocytomas and paragangliomas: A retrospective cohort study, systematic review and meta-analysis

      ea0086p194
    • Repurposing Nandrolone, an Anabolic Steroid drug for Cancer Therapeutics: An In silico approach

      ea0086p195
    • Prevalence of vitamin B12 deficiency in neuroendocrine tumour-Single Centre Experience

      ea0086p196
    • Immunotherapy and its impact on the endocrine system: Guidelines a need of the hour

      ea0086p197
    • Acute life-threatening hyponatremia post first chemotherapy cycle with epirubicin and cyclophosphamide: Need for changing protocols?

      ea0086p198
    • Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer

      ea0086p322
    • Managing PPGL surveillance in the COVID-19 recovery period: experience of a newly-established Endocrine Genetics MDT

      ea0086p323
  • Metabolism, Obesity and Diabetes
  • • Spatial proteomics of skeletal muscle isolates high-fat diet produced inflammatory events

      ea0086p48
    • Investigating NtsR1-expressing neurons extending from the duodenum to pancreas

      ea0086p49
    • Single-nucleus RNA sequencing identifies wide-ranging changes in gene expression in mouse nodose ganglia cell populations in response to fasting

      ea0086p50
    • Regulation of 5-HT secretion from human duodenal enterochromaffin cells

      ea0086p51
    • Nrf2 activator Sulforaphane attenuates maternal adiposity and hepatic steatosis

      ea0086p52
    • Pharmacological potential of annona squamosa ameliorates insulin secretion from clonal pancreatic [beta]-cells and regulates blood glucose in type 2 diabetic rats

      ea0086p53
    • Metabolic Endotoxemia impacts mitochondrial function and adipocyte browning in a depot specific manner in Human abdominal adipose tissue

      ea0086p54
    • Effect of sulforaphane, an activator of the Nrf2 antioxidant defence pathway, on maternal adiposity in a model of diet-induced insulin resistant pregnancy

      ea0086p55
    • Macrophage-specific SHIP2 knockdown mice display sex-dependent liver steatosis

      ea0086p56
    • Parameters associated with neutrophil to lymphocyte ratio in patients with severe obesity

      ea0086p57
    • Weight reduction in diabetic adult male wistar rats model using aqueous and ethanolic extract of Zingeber officinale and Allium sativum

      ea0086p58
    • The role of glucocorticoid activation by 11bHSD1 for muscle wasting in a mouse model of renal impairment

      ea0086p59
    • Asprosin exerts pro-inflammatory effects via the TLR4 pathway in THP-1 macrophages

      ea0086p60
    • Growth hormone increases at the onset of lactation and promotes mammary metabolism: Insights from clinical and cellular studies

      ea0086p61
    • Effects of ethanolic extract of Allium Sativum L on the hippocampus of male Wistar rats with Streptozotocin (STZ)- induced brain insulin resistance

      ea0086p62
    • Is SIMBA impactful in improving participants' confidence in managing cases of obesity via simulation-based learning, irrespective of the mode of attendance or country of residence?

      ea0086p63
    • Novel contrast enhanced ultrasound imaging approaches to understand and treat gastrointestinal disease

      ea0086p64
    • Assessment of the Acute Effects of Rice and Potato Protein Isolate Intake on Markers of Glycaemic Regulation in Healthy Males Using a Randomised Study Design

      ea0086p65
    • Assessing the effect of different fatty acid compositions on in vitro cellular models of human hepatocytes

      ea0086p66
    • Intrahepatocellular insulin resistance and lipid droplet morphology: Influence of fatty acid composition

      ea0086p67
    • The perils of steroids and salt in Covid-19 associated Diabetes

      ea0086p68
    • The effect of novel adipokine asprosin on mitochondrial function in human airway epithelial cells

      ea0086p69
    • Liver specific microparticles to improve islet transplantation outcomes in Type 1 diabetes

      ea0086p70
    • From pathological insulin resistance to pathological insulin sensitivity - a rare case of insulinoma unmasked by bariatric surgery

      ea0086p71
    • A novel compound heterozygous variant of Gitelman’s syndrome in a patient with Sjorgren’s syndrome: latent rather than acquired?

      ea0086p72
    • The Unusual Suspects: Steroid receptors & hormones found in the mitochondria

      ea0086p73
    • Ferric-induced hypophosphatemia ironed out with electrolyte replacement: a case report

      ea0086p74
    • Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a 'Nearly Post COVID-19' World

      ea0086p75
    • Plasma Erythroferrone is negatively correlated with total body fat

      ea0086p76
    • Investigating the effects of experimentally induced insulin dysregulation on adiponectin concentrations in metabolically healthy ponies

      ea0086p77
    • Reversal of Diabetes after 25 years - Not a chronic disease anymore?

      ea0086p78
    • Severe rhabdomyolysis secondary to rapid correction of hyponatremia in a patient with psychogenic polydipsia

      ea0086p79
    • Predictors of Diabetic Peripheral Neuropathy: A Multi-Center Cross-Sectional Study

      ea0086p80
    • Altered Androgen Metabolism in Rheumatoid Arthritis Influences Synoviocyte Function

      ea0086p81
    • The prevalence and management of vitamin D deficiency in people with type two diabetes: Systematic review

      ea0086p82
    • Examining Smartphone Use During Mealtime and Its Association With Eating Disorders Among Adolescents

      ea0086p83
    • Chronic heart failure in hospitalized elderly subjects with diabetes type  2

      ea0086p84
    • Fluoxetine Contributing to Non-diabetic Hypoglycaemia

      ea0086p85
    • Real-world effectiveness and safety of semaglutide for weight loss

      ea0086p86
    • Proliferative diabetic retinopathy as a presenting feature of Type 1 Diabetes mellitus- A case report

      ea0086p87
    • Temporal periods of mild hyperglycaemia in pregnancies complicated by gestational diabetes and LGA alter placental transcriptomic networks associated with vascularisation and M2 hofbauer cell polarisation

      ea0086p199
    • The American lifestyle-induced obesity syndrome diet (ALIOS) in mice alters the diversity and composition of the gut microbiome

      ea0086p200
    • Angiotensin II dependent pericyte activation causes neuropathic pain in a type-2 rodent model of diabetes

      ea0086p201
    • Identifying the amino acids which mediates the effect of protein on glucagon release

      ea0086p202
    • Monitoring obesity-induced hyperglycaemia and insulin sensitivity in obese murine pregnancy

      ea0086p203
    • Clinical and cellular studies highlight a role for insulin at the onset of lactation in promoting mammary glycolysis and oxidative phosphorylation

      ea0086p204
    • UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors

      ea0086p205
    • Circulating levels of adipose-derived lipokines correlate positively with fasting insulin in states of increased insulin insensitivity in humans

      ea0086p206
    • Vitamin D₃ supplementation improves glucose metabolism in the offspring of fructose-induced Sprague-Dawley rats

      ea0086p207
    • Serum Bile Acid Measurements in Women of European and South Asian Descent with or without Gestational Diabetes Mellitus

      ea0086p208
    • Vitamin B12 deficiency induces de novo lipogenesis and lipid oxidation in human placental trophoblasts

      ea0086p209
    • Elucidating endothelial-derived molecules with potential anti-obesity properties via crosstalk with enterocytes and gut microbiota

      ea0086p210
    • Investigating the effect of obesity on gut damage, systemic inflammation, enhanced asthma severity due to gut derived bacteria, endotoxin

      ea0086p211
    • Can improved glycaemic control improve NAFLD independent of weight loss in patients with type 2 diabetes?

      ea0086p212
    • Differentially expressed genes in insulin resistant macrophages are shared across multiple diabetes associated morbidities

      ea0086p213
    • C-peptide assessments- are we doing it correctly?

      ea0086p214
    • Metabolic syndrome and obesity in IBD patients: how common?

      ea0086p215
    • Simvastatin regulates Il10 gene expression in male and female murine macrophages

      ea0086p216
    • Ethnic differences in diabetes remission following bariatric surgery

      ea0086p217
    • Remote Blood Glucose Level monitoring amongst women with Gestational Diabetes Mellitus during COVID-19

      ea0086p218
    • Clinical profile and risk factors for severity and mortality of post-COVID-19 mucormycosis

      ea0086p219
    • Endotoxin Impairs Brown Fat Phenotype and Mitochondrial Function in 2D and 3D Brown Adipocytes Models

      ea0086p220
    • Pregnancy following islet cell transplantation in a woman with type 1 diabetes and autoimmune Addison’s disease

      ea0086p221
    • Investigating the effects of 5.5 mmoL vs 25 mmoL glucose concentration in culture media on LHCN-M² cell viability, proliferation, metabolism and differentiation

      ea0086p222
    • Micronutrient concentrations and their associations with BMI in bariatric surgery patients

      ea0086p223
    • The importance of identifying severe hyponatraemia early in hospitalised patients and early referral to endocrinology. Our experience in a large secondary care teaching hospital

      ea0086p224
    • Characterisation of the mechanism of long-chain fatty acid uptake in human-derived pancreatic beta cells

      ea0086p225
    • Use of Freestyle Libre^® In People with Type 2 Diabetes Mellitus in Specialist Diabetes Clinic

      ea0086p226
    • Covid - 19 Vaccination Acceptance Among Type 2 Diabetes Patients In University of Medical Science Teaching Southwest Nigeria

      ea0086p227
    • Self-care pattern in patient living with type 2 diabetes Southwest, Nigeria

      ea0086p228
    • FreeStyle Libre 2 use in non-diabetes setting - A case of post-bariatric surgery dumping syndrome causing severe hypoglycaemia in pregnancy

      ea0086p229
    • Impact of COVID-19 Lockdown on Biomarkers of Diabetes and Dyslipidaemia

      ea0086p230
    • Relationship between gestational diabetes mellitus and incidence of post-delivery dysglycaemia

      ea0086p231
    • Transient Diabetes mellitus post Covid 19 vaccination

      ea0086p232
    • Hyperglycemia and clinical outcomes among patients with acute ischemic stroke

      ea0086p233
    • Hyperglycaemia in patients with Acute Coronary syndromes (ACS): Retrospective audit data from Barnsley Hospital NHS Foundation Trust

      ea0086p234
    • Diabetic Ketoacidosis (DKA) in Maturity Onset Diabetes of Young (MODY) associated with Sodium-glucose co-transporter-2 inhibitors (SGLT2i)

      ea0086p235
    • Specialist Weight Management Service: COVID19 did not break our spirit

      ea0086p236
    • Metformin inefficiency in vitamin B12 deficient hepatocytes to lower lipids is alleviated via Adiponectin-AMPK axis

      ea0086p324
    • A potential role for the Wnt signalling pathway in the development of obesity: insights from animal models

      ea0086p325
    • Examining the relationship between gestational diabetes, maternal pre-pregnancy body mass index (BMI) and large for gestation age neonates by ethnicity

      ea0086p326
    • 'Don't Let them dry'—Hyponatraemia in Covid-19 (a real-world analysis)

      ea0086p327
    • Vernonia amygdalina Alleviates Neurodegenerative Effects of High Fat Diet and Streptozotocin-Induced Type 2 Diabetes Mellitus in the Hippocampi of Adult Male Wistar Rats

      ea0086p328
    • POMC mutation in a canine obesity model: dogs with [beta]-MSH and [beta]-endorphin deletion have increased hunger and low resting metabolic rate

      ea0086p329
    • Glicentin concentrations following Liraglutide treatment in patients with overweight/obesity

      ea0086p330
    • Mass Spectrometry Imaging to Investigate Carnitine Metabolism during Brain Ageing

      ea0086p331
    • Digital Communication through Covid - A free NHS App for patients with Type 1 diabetes improves accessibility and self-management

      ea0086p332
    • SIMBA for Students - teaching endocrinology to pre-clinical medical and pharmacy students through online simulation: a pilot study

      ea0086p333
    • Epidemiology of Diabetes Mellitus in Children in Kazakhstan: Data from Unified National Electronic Health System 2014-2019

      ea0086p334
    • Assessing GLP-1 Agonists and DPP-IV Inhibitor Prescribing in the Management of Type 2 Diabetes during COVID-19

      ea0086p335
    • Comparison of global rating scale scores of Simulation via Instant Messaging -Birmingham Advance (SIMBA) participants from high- and low- and middle-income countries of residence

      ea0086p336
    • A case of GLP-1 RA-induced hypoglycaemia following RYGB in a patient with Type II Diabetes and autonomic dysfunction

      ea0086p337
    • Unusual late presentation of maturity onset diabetes of young (MODY)

      ea0086p338
    • Diabetic striatopathy: A rare presentation as stroke mimic and focal seizure

      ea0086p339
    • "Severe Lipaemia" with triglyceride levels above 100 mmol/L: successfully treated with insulin therapy alone

      ea0086p340
    • New onset diabetes triggered by use of growth hormone secretogogue for body building, a case report

      ea0086p341
  • Neuroendocrinology and Pituitary
  • • Cabergoline in acromegaly - a multicenter, retrospective, cohort study of non-irradiated patients using current criteria for disease control

      ea0086p88
    • Somatic sequencing in an enriched cohort of recurrent non-functioning pituitary adenomas

      ea0086p89
    • Phosphoproteomics analysis of aryl hydrocarbon receptor interacting protein (AIP) knockout cells reveals AIP-mediated kinase signalling cascades

      ea0086p90
    • Diabetes insipidus safety: Automated electronic records alert to identify patients with diabetes insipidus in hospital

      ea0086p91
    • Natural history of non-functioning pituitary microadenomas - results from the UK NFA consortium

      ea0086p92
    • Circadian/diurnal rhythm profiles of serum and salivary melatonin, cortisol and cortisone, determined by liquid chromatography tandem mass spectrometry (LC-MS/MS)

      ea0086p93
    • Gene-chromatin regulatory circuits driving stemness in the anterior pituitary

      ea0086p94
    • Optimising the Insulin Tolerance Test: Cortisol Thresholds on Abbott Platforms should be lowered to 416 nmol/L

      ea0086p95
    • A case of chronic hyponatremia secondary to SIADH treated with low dose Tolvaptan to prevent recurrent hospital admission and proven cost effective

      ea0086p96
    • Aberrant cyclic GMP-AMP synthase stimulator of interferon genes signalling in an AIP mutant cell line

      ea0086p97
    • The pituitary patients' experiences pre and during the Covid-19 pandemic

      ea0086p98
    • Pseudo-Cushing’s syndrome in the context of intense physical exercise and underlying eating disorder - pitfalls of interpreting investigations in patients with body dysmorphia

      ea0086p99
    • Adipose tissue and glycemic changes in patients with surgically treated acromegaly

      ea0086p100
    • A rare case of silent Gonadotroph Adenoma presenting with secondary infertility, oligomenorrhea in a female patient with a history of polycystic ovarian syndrome

      ea0086p101
    • Early Onset Neurosarcoidosis with Delayed Severe Hypercalcaemia

      ea0086p102
    • A rare case of Erdheim-Chester disease as the underlying cause of cranial diabetes insipidus

      ea0086p103
    • Patient-reported use of physiotherapy services in rare endocrine conditions - a quantitative study

      ea0086p104
    • Case Series: Primary / neo-adjuvant ¹³¹I-MIBG therapy as a safe and effect treatment in the management of pheochromocytoma / paraganglioma

      ea0086p105
    • Identifying and characterising variants in patients with pachydermoperiostosis

      ea0086p106
    • Severe hyponatremia-A manifestation of new Pituitary metastases in Renal Cell Cancer

      ea0086p107
    • Dopamine agonist intolerance in prolactinoma- A management challenge to endocrinologist

      ea0086p108
    • A TSH-secreting pituitary adenoma cured from SSA monotherapy alone: Disease free more than three years after stopping treatment

      ea0086p109
    • Retrospective analysis of clinical, biochemical, radiological features of Craniopharyngioma

      ea0086p110
    • A rare Presentation of Carcinoid Crisis Following Radioactive Iodine Treatment for Thyroid Cancer in a Patient with Metastatic Midgut Neuroendocrine Tumour

      ea0086p111
    • Primary papillary epithelial tumor of the pituitary- a challenge to diagnosis; first reported case from Sri Lanka

      ea0086p112
    • A Rare Case of Radiation-Induced Sarcoma in Acromegaly - Diagnostic challenges

      ea0086p113
    • Skull base lymphoma causing hypopituitarism

      ea0086p114
    • Pituicytoma mimicking as a Non-functioning pituitary macroadenoma

      ea0086p115
    • Insulinoma presenting as Seizures - Case Report of a 16-year-old young woman

      ea0086p116
    • Acetate ameliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

      ea0086p237
    • Anticoagulation practice for venous thromboembolism prophylaxis in patients with Cushing’s Syndrome - a Society for Endocrinology survey of UK Centres

      ea0086p238
    • A zebrafish model of AIP loss of function

      ea0086p239
    • UK practice on incidental (presumed) non-functioning pituitary microadenomas: a 13-year interval comparison

      ea0086p240
    • Understanding the molecular pathophysiology of stress on the developing and adult brain

      ea0086p241
    • FUZ is required for SHH-mediated pituitary development

      ea0086p242
    • Imaging surveillance of completely resected gastroenteropancreatic neuroendocrine tumors is associated with high levels of radiation exposure

      ea0086p243
    • Neuroendocrine tumour (NETs) patient experience of switching to generic somatostatin analogue during the COVID-19 pandemic

      ea0086p244
    • An investigation into discrepancies between serum insulin-like growth factor 1 (IGF-1) concentrations and clinical presentation in the assessment of acromegaly

      ea0086p245
    • A novel presentation of primary hyperparathyroidism for the Val804Met mutation

      ea0086p246
    • Surgical management of prolactinomas in patients with dopamine agonist-associated impulse control disorders or who are deemed at 'high risk'

      ea0086p247
    • Vasopressin in Not a Strong Stimulus for ACTH-Cortisol Secretion In Humans

      ea0086p248
    • Acute hypoglycemia as the presenting manifestation secondary to pituitary metastasis in a patient with malignant melanoma

      ea0086p249
    • A case report of Takotsubo cardiomyopathy associated with pituitary apoplexy

      ea0086p250
    • ACTH dependent Cushing’s syndrome due to a pituitary macroadenoma presenting with acute Type B aortic dissection, severe hypercortisolism and resistant hypertension

      ea0086p251
    • Impulse Control Disorder in Patients on Dopamine Agonist

      ea0086p252
    • Safe Reduction in Short Synacthen Testing to Assess Hypothalamo-Pituitary Axis in patients on Corticosteroids

      ea0086p253
    • Prevalence of cancer in a cohort of acromegaly patients

      ea0086p254
    • Pituitary mass and Pan hypopituitarism- A rare case of Langerhans Cell Histiocytosis

      ea0086p255
    • Two cases of acromegaly: the role of the dentist in early detection

      ea0086p256
    • The modulatory role of curcumin and quercetin on Drosophila GSK-3: a potential therapeutic intervention in Parkinson’s disease

      ea0086p257
    • Unusual presentation of neurohypophysitis

      ea0086p258
    • Successful use of recombinant human TSH prior to radioiodine therapy in an acromegaly patient with differentiated thyroid cancer and pituitary insufficiency

      ea0086p259
    • Cushing’s Syndrome - A medical emergency and diagnostic challenge

      ea0086p260
    • A rare case of multicentric glioblastoma causing panhypopituitarism: A case report

      ea0086p261
    • Dilated Cardiomyopathy as initial presentation of Acromegaly

      ea0086p262
    • Pitfalls in the Biochemical Evaluation of Cushing’s Syndrome: A Challenging Case and Literature Review

      ea0086p263
    • Diabetes insipidus following a non-acute presentation of pituitary apoplexy - a rare presentation

      ea0086p264
    • Not just a prolactinoma- Conservative management of co-secretory macroadenoma

      ea0086p265
    • Variants in the neurodevelopmental gene bone morphogenetic protein/retinoic acid inducible neural-specific 2(BRINP2) are associated with severe delayed puberty

      ea0086p342
    • Variants in Methyl-CpG-binding protein 2 (MECP2) are associated with X-Linked Central Precocious Puberty

      ea0086p343
    • CRN04894: an oral, nonpeptide adrenocorticotropic hormone (ACTH) receptor antagonist decreases basal and stimulated cortisol secretion in healthy volunteers

      ea0086p344
    • Amyloid Beta Expression in the Amygdala of Aged Rhesus Macaques: Effect of Hormone Replacement Therapy

      ea0086p345
    • Immune checkpoint inhibitor related hypothalamus pituitary adrenal axis dysfunction: A retrospective study in Derriford Hospital

      ea0086p346
    • Targeted Profiling of Endogenous Steroids in Mouse Plasma Using Liquid Chromatography-Mass Spectrometry Approach

      ea0086p347
    • Use of Neurosteroids to Treat a Neuronal Antibody-mediated Seizure Model

      ea0086p348
    • Co-morbidity of alzheimer-like dementia and type-2 diabetics mellitus: possible therapeutic effect of virgin coconut oil

      ea0086p349
    • Central diabetes insipidus associated with Covid-19 infection and vaccination - could this be a 'common' phenomenon?

      ea0086p350
    • Hypophysis associated with Crohn’s disease - Think DI as well as GI in dehydrated thirsty Crohn’s disease patients with rising sodium!

      ea0086p351
    • The heart bleeds - complex management of a patient with acromegaly, cardiomyopathy and mechanical mitral valve

      ea0086p352
    • The burden of heatwave-related profound hyponatraemia: Is the climate change making these events more likely?

      ea0086p353
    • Primary CNS lymphoma presenting with cranial diabetes insipidus - a case series

      ea0086p354
    • An unusual case of (extremely) delayed ACTH deficiency following pituitary gamma-knife radiotherapy

      ea0086p355
  • Reproductive Endocrinology
  • • Quantifying the Variability in the Outpatient Assessment of Reproductive Hormone levels

      ea0086p117
    • Determining the impact of FSH glycosylation variants on the pre-antral follicle transcriptome in the ageing ovary

      ea0086p118
    • FSH glycosylation variants differentially modulate FSHR trafficking

      ea0086p119
    • Female reproductive health disturbance associated with the COVID-19 pandemic persists despite improving mental health- a longitudinal observational study

      ea0086p120
    • Tool development for the in vivo analysis of the physiological role of FSHR oligomerisation

      ea0086p121
    • Are elevated red blood cell parameters coincidental or correlated in patients with Turner syndrome?

      ea0086p122
    • Androgen receptor splice-variants in granulosa-lutein cells of women with polycystic ovary syndrome (PCOS)

      ea0086p123
    • Divergent G-protein signal control at the very early endosome (VEE) from the dually coupled luteinizing hormone receptor (LHR)

      ea0086p124
    • Simulation via Instant Messaging - Birmingham Advance helps to narrow the gap of knowledge and expectations between clinicians and women with polycystic ovary syndrome: A SIMBA-PCOS mixed-method study

      ea0086p125
    • Experience of Prescribing Testosterone Gel to Menopausal Women at a Single UK Centre: The Biochemistry and The Patent Experience

      ea0086p126
    • Interleukin-6 increases at the onset of lactation and promotes mammary glycolysis: insights from clinical and cellular studies

      ea0086p127
    • Therapeutic Mechanism of Aqueous Extract of Momordica Against Monosodium Glutamate Induced Ovarian Toxicity

      ea0086p128
    • Adipocytes-Derived Extracellular Vesicle-miR-26b Induces the process of Polycystic Ovary Syndrome

      ea0086p129
    • Turner Syndrome - a case report illustrating the importance of early gynaecology input for women who are unable to tolerate progestins

      ea0086p130
    • Identification of a transcription factor that modulates ER[alpha]-Dependent Hypothalamic Estrogen Sensing

      ea0086p266
    • Spatial and ligand-directed control of Prostaglandin EP2 signalling

      ea0086p267
    • Cluster analysis with routine hormonal parameters identifies two distinct subsets of polycystic ovary syndrome (PCOS)

      ea0086p268
    • Metformin Exposure In-Utero Influences Placental Pathways Associated with Mitochondrial Activity

      ea0086p269
    • How do endocrinologists and GPs perceive contemporary transgender care?: results from a qualitative study of UK doctors

      ea0086p270
    • Relationships between adipocyte fatty acid-binding protein with parameters of obesity in women with polycystic ovary syndrome

      ea0086p271
    • Vernonia amydalina leaf extract ameliorates hyperandrogenism and oxidative stress in polycystic ovarian syndrome-induced Sprague-Dawley rats

      ea0086p272
    • Interleukin-15, a pleiotropic cytokine, is increased in the mammary gland during lactation

      ea0086p273
    • Investigating hormones triggering the onset of sustained lactation (INSIGHT) pilot study

      ea0086p274
    • Follicle Sizes That are Most Likely to Yield Oocytes During In Vitro Fertilisation (IVF) Treatment

      ea0086p275
    • Is there a consensus for Management of Hormone Replacement for Males and Females with Hypogonadism in the UK? SfE national survey

      ea0086p276
    • Comparative analysis of the fertility-enhancing potentials of graded doses of Newbouldia laevis and Zinc in male Wistar rats

      ea0086p277
    • Severe Virilization due to ovarian hyperthecosis

      ea0086p278
    • Growth hormone therapy in the management of short stature due to turner syndrome in Nigeria: a case report

      ea0086p279
    • The impact of body mass index and lifestyle factors on serum concentrations of reproductive and thyroid hormones in premenopausal women

      ea0086p356
    • The rapeutic potentials of Vernonia amygdalina in letrozole and high-fat diet induced polycystic ovary syndrome in female wistar rats

      ea0086p357
    • The reproductive years: the experience of women attending routine diabetes care

      ea0086p358
    • A rare case of male infertility; XX male syndrome…

      ea0086p359
    • Reduced accuracy of gold top blood collection tubes for reproductive hormone profiling in capillary blood samples

      ea0086p360
    • Genomic imprinting and maternal adaptations to pregnancy

      ea0086p361
    • Clinical utility of GnRH analogues in female androgen excess: diagnostic and therapeutic implications

      ea0086p362
    • Turner Syndrome with 45X gene presenting with Menorrhagia: A diagnostic dilemma

      ea0086p363
  • Thyroid
  • • Therapeutic database of anti-thyroid medication over 10 years in northern ireland (NI) 2010-2019: trends, demographics and deprivation

      ea0086p131
    • Reconsidering the role of thyroidectomy in thyroid eye disease (TED) patients

      ea0086p132
    • Comparison of supervised rapid thyroxine absorption test in refractory and well-controlled primary hypothyroid patients in a tertiary care center in Sri Lanka and formulation of a prediction model to predict the expected FT4 rise during the test

      ea0086p133
    • High TRAB at the Time of Radio-iodine therapy (RAIT) Predicts Persistent Hyperthyroidism

      ea0086p134
    • Thyroid function testing in people treated with Lithium: We are doing more thyroid tests than is necessary

      ea0086p135
    • Evaluation of Prevalence and Causes of Thyroid dysfunction in Hospitalized Patients

      ea0086p136
    • Treatment-refractory hypothyroidism probably secondary to concurrent phenytoin administration

      ea0086p137
    • Antithyroid Arthritis syndrome: A rare side effect

      ea0086p138
    • A rare case of Hashimoto’s encephalopathy

      ea0086p139
    • Review of Nottingham University Hospital Antenatal Thyroid Service for Patients with Autoimmune Hyperthyroidism

      ea0086p140
    • Are we following NICE guidelines in classifying hyperthyroid patients presenting to endocrinology clinic in a DGH?

      ea0086p141
    • Thyroid storm triggered by RSV pneumonia

      ea0086p142
    • A delayed diagnosis of Graves' disease in a patent with severe hyperthyroidism-associated hypercalcaemia

      ea0086p143
    • Human chorionic gonadotropin (hCG) mediated thyrotoxicosis secondary to metastatic choriocarcinoma

      ea0086p144
    • Iodine-based contrast media-induced hyperthyroidism in a patient with underlying subclinical hyperthyroidism and multinodular goitre

      ea0086p145
    • Three times unlucky or a unifying endocrine diagnosis?

      ea0086p146
    • An Unusual Presentation of An Autoimmune thyroid Disease

      ea0086p147
    • Novel targets determination among patients with angioinvasive differentiated thyroid cancer

      ea0086p280
    • The potential interaction between medical treatment and radioiodine treatment success: a systematic review

      ea0086p281
    • The future of TSH receptor antibody (TRAb) testing at university hospitals birmingham (UHB)

      ea0086p282
    • Abnormalities of thyroid function tests in patients receiving Immune Checkpoint Inhibitor Treatment for Cancer; importance of a wide-angled lens

      ea0086p283
    • The Barnet Thyrotoxicosis Pathway - A Quality Improvement Project

      ea0086p284
    • Preoperative Rapid Optimisation in poorly controlled Graves' disease: An outpatient experience during the COVID-19 pandemic

      ea0086p285
    • Graves' thyrotoxicosis and spontaneous coronary artery dissection: Is there a link?

      ea0086p286
    • Primary MALT lymphoma of thyroid with hypothyroidism and absence of Hashimoto’s disease

      ea0086p287
    • Arterial Thrombus in a Graves thyrotoxicosis - Hyper-coagulable state and Hyperthyroidism

      ea0086p288
    • Graves' disease with benign ethnic neutropenia-a grave combination

      ea0086p289
    • Late relapse of thyroid eye disease (TED)

      ea0086p290
    • Clinical case of Alemtuzumab induced thyroid storm requiring urgent inpatient thyroidectomy

      ea0086p291
    • Thyroid Storm presenting without fever

      ea0086p292
    • Pfizer vaccine induced subacute thyroiditis

      ea0086p293
    • A Challenging Case of Oscillating Hashimoto’s thyroiditis and Hyperthyroidism

      ea0086p294
    • Radioactive Iodine treatment (RAI) for benign thyroid disease: ESHT outcomes

      ea0086p295
    • Euthyroidism: following a course of radio iodine therapy for Graves' disease

      ea0086p296
    • A rare case of agranulocytosis secondary to carbimazole medication complicated by a prolonged COVID-19 infection

      ea0086p297
    • Evaluating the progression to hypothyroidism in preconception euthyroid thyroid-peroxidase antibody positive women

      ea0086p364
    • A rise in the incidence of Graves' disease in North West Wales during the COVID-19 pandemic: an effect of the SARS-CoV-2 virus or vaccine?

      ea0086p365
    • Use of Burch-Wartofsky score when assessing the severity of hyperthyroidism, a retrospective study

      ea0086p366
    • L-T3 Prescribing & Deprescribing - Single Centre Experience

      ea0086p367
    • Falsely elevated serum TSH in a mother and her four children

      ea0086p368
    • A rare case of profound refractory hypothyroidism: Compliance or Formulation issue?

      ea0086p369
  • Nursing Practice
  • • Incidence of COVID-19 in People with Primary Adrenal Insufficiency in the UK and Reported Self-Management - A prospective study

      ea0086p148
    • Our Grampian experience of establishing an endocrine nurse specialist service within the Gender identity clinic

      ea0086p149
    • Use of Health Literacy Tools to Improve Written Information for Patients with or at Risk of Adrenal Insufficiency

      ea0086p150
    • Transforming 'Late Effects' care post Covid-19

      ea0086p151