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Endocrine Abstracts (2022) 84 PS2-10-89 | DOI: 10.1530/endoabs.84.PS2-10-89

ETA2022 Poster Presentations Nodules & Cancer (10 abstracts)

Follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P) showed peculiar ultrasonographic features compared to follicular variant of papillary thyroid carcinoma (FV-PTC), follicular carcinoma (FTC) and follicular adenoma (FA)

Luigi De Napoli 1 , Antonio Matrone 2 , Carla Gambale 2 , Erica Pieroni 1 , Giulia Boni 1 , Aleksandr Aghababyan 1 , Carlo Enrico Ambrosini 1 , Liborio Torregrossa 3 , Fulvio Basolo 3 , Gabriele Materazzi 1 & Rossella Elisei 2


1Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa; 2Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa; 3Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa


Background: Up to 2016, NIFT-P was considered a non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FV-PTC) and was reclassified and downgraded to a pre-malignant lesion. However, if these nodules have peculiar ultrasonographic features able to pre-operatively suggest their histology is still a matter of discussion. We evaluated a large series of NIFT-P, FV-PTC, FTC, and FA to characterize their ultrasonographic features.

Methods: We reviewed pre-operative digital ultrasound images and reports of NIFT-P (n = 116), FV-PTC (n = 170), FTC (n = 76), and FA (n = 90) evaluated at the Endocrine Unit of the University Hospital of Pisa, and surgically treated at the Endocrine Surgery Unit of the same hospital. For each nodule we evaluated the following ultrasonographic features: size, composition, echogenicity, shape, margins, and calcifications.

Results: In table 1, the differences in ultrasonographic appearance among the four considered histologies, were highlighted.

NIFT-P a
(n = 116)
FV-PTC b
(n = 170)
pa vs bFTC c
(n = 76)
pa vs cFA d
(n = 90)
p a vs d
Nodule max diameter (cm)Median (IQR)2.1 (1.3-3.7)2.3 (1.5-3.7)0.273.1 (1.8-4.4)<0.012.7 (1.8-4.4)<0.01
US features - %
CompositionSolid
Cystic
Mixed
94.8
-
5.2
97.1
0.6
2.4
0.1696.1
2.6
1.3
0.1594.4
3.3
2.2
0.10
EchogenicityAnechoic
Hypoechoic
Isoechoic
Hyperechoic
-
31
63.8
5.2
0.6
31.8
61.8
5.9
0.852.6
53.9
40.8
2.6
<0.013.3
57.8
36.7
2.2
<0.01
MarginsWell defined
Lobed or irregular
96.6
3.4
84.7
15.3
<0.0188.2
11.8
0.0297.8
2.2
0.60
CalcificationsAbsent
Macro
Peripheral
Micro
Hyperechoic spots
94
1.7
0.9
2.6
0.9
70
9.4
6.5
4.7
9.4
<0.0176.3
5.3
3.9
9.2
5.3
0.0187.8
4.4
1.1
4.4
2.2
0.61
Taller than wideYes
No
1.7
98.3
10
90
<0.0113.2
86.8
<0.01-
100
0.21
HaloYes
No
91.4
8.6
81.2
18.8
0.0269.7
30.3
<0.0168.9
31.1
<0.01

Conclusion: While FV-PTC and FTC showed significantly more frequent ultrasonographic features suspicious for malignancy; most NIFT-P showed ultrasonographic features suggestive for benignity, similar to FA.

Volume 84

44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

European Thyroid Association 

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