ETA2022 Poster Presentations Thyroid Cancer BASIC (10 abstracts)
Use of long noncoding rnas for molecular diagnosis of thyroid cancer
Daham Kim 1 , Juyeon Yu 1 , Jiwon Kim 1 , Yoon-a Hwang 1 , Jin Kyong Kim 2 , Cheol Ryong Ku 1 , Jung Hyun Yoon 3 , Jin Young Kwak 3 , Kee-Hyun Nam 2 & Eun Jig Lee 1
1Yonsei University College of Medicine, Department of Internal Medicine, Seoul, Korea, Rep. of South; 2Yonsei University College of Medicine, Department of Surgery, Seoul, Korea, Rep. of South; 3Yonsei University College of Medicine, Department of Radiology, Seoul, Korea, Rep. of South
Objective: Improved molecular testing for common somatic mutations and the identification of mRNA and microRNA expression classifiers are promising approaches for the diagnosis of thyroid nodules. However, there is a need to improve the diagnostic accuracy of such tests in identifying thyroid cancer. Recent findings have revealed a crucial role of lncRNAs in gene modulation. Thus, we aimed to evaluate the diagnostic value of selected lncRNAs from The Atlas of Noncoding RNAs in Cancer (TANRIC) thyroid cancer dataset.
Methods: LncRNAs in TANRIC thyroid cancer dataset that have significantly increased or decreased expression in thyroid cancer tissues were selected as candidates for thyroid cancer diagnosis. Surgical specimens from patients who underwent thyroidectomy were used to determine the separation capability of candidate lncRNAs between malignant and benign nodules. Fine needle aspiration samples were obtained and screened for candidate lncRNAs to verify their diagnostic value.
Results: LRRC52-AS1, LINC02471, LINC02082, UNC5B-AS1, LINC02408, MPPED2-AS1, LNCNEF, LOC642484, ATP6V0E2-AS1, and LOC100129129 were selected as the candidate lncRNAs. LRRC52-AS1, LINC02082, UNC5B-AS1, MPPED2-AS1, LNCNEF, and LOC100129129 expression levels were significantly increased or decreased in malignant nodules compared to those in benign nodules or paired normal thyroid tissues. The combination of LRRC52-AS1, LINC02082, and UNC5B-AS1 showed favorable results for the diagnosis of thyroid cancer from fine needle aspirates, with 89 % sensitivity and 100 % specificity.
Conclusions: LncRNA expression analysis could be a promising approach for advancing the molecular diagnosis of thyroid cancer. Further studies are needed to identify lncRNAs of additional diagnostic value.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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