ETA2022 Poster Presentations Hypothyroidism Treatment (10 abstracts)
TSH levels assessment in hypothyroid patients treated with liquid or tablet l-thyroxine
Alessandro Antonelli 1 , Silvia Martina Ferrari 2 , Giusy Elia 1 , Francesca Ragusa 1 , Sabrina Rosaria Paparo 1 , Valeria Mazzi 1 , Chiara Botrini 1 & Poupak Fallahi 3
1University of Pisa, Department of Surgical, Medical and Molecular Pathology and Critical Area, Pisa, Italy; 2University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy; 3University of Pisa, Department of Translational Research of New Technologies in Medicine and Surgery, Pisa, Italy
Objective: Tablet levothyroxine (L-T4) is the common used therapy for hypothyroidism. In order to assess a good compliance to the therapy, treated patients are monitored with the execution of annual thyroid hormonal test. The stability of TSH levels in hypothyroid patients (with no malabsorption issues), treated with liquid L-T4, compared to that of the patients treated with tablet L-T4, remained a poorly understood topic. This study has the purpose to deepen this issue.
Methods: We selected patients who reported the following criteria: a) normal serum TSH levels at the basal evaluation; b) no malabsorption or drug interference issues; c) in treatment with liquid or tablet L-T4. Hypothyroid patients (matched by gender and age) were compared according to the used drug formulation; 653 subjects were in treatment with liquid L-T4, and 329 subjects with tablet L-T4. We performed a two year follow-up, during which the serum TSH, FT3, FT4 levels were annually measured.
Results: Gender, age, body mass index, history of chronic autoimmune thyroiditis, initial TSH level, and L-T4 dose were the parameters evaluated at the first abnormal TSH value. These parameters, at the time of initial normal TSH, were not associated significantly with time to abnormal TSH values. After 1 year, TSH values were normal in 86% of the patients who were in treatment with L-T4 liquid formulation, whereas only in 80% of patients who followed a tablet L-T4 therapy. After 2 years, normal TSH values were registered in 84% of patients who were treated with L-T4 liquid formulation, while only in 74% of patients who received tablet L-T4 (P < 0.05).
Conclusion: These data showed that in the long term follow-up, liquid L-T4 can permit to maintain more efficiently normal TSH levels in hypothyroid patients, than tablet L-T4.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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