Endocrine Abstracts

Objectives: Cardiovascular disease encountered the leading cause of death in thyroid cancer survivals exceeding death by cancer itself. Etiological factors are the therapy used and the duration of exposure to this it, the diagnosis of cancer itself, or the factors that led to this cancer. We aim to evaluate cardiometabolic risk factors in an Algerian cohort of thyroid cancer survivals.

Methods: The study includes a cohort of patients followed in the thyroid cancer register in the endocrinology department of Constantine University Hospital during the period between January 2020 and June 2021. Patients have received a complete examination in addition to an ECG and a fasting blood sample including fasting blood sugar, complete lipid profile, TSH, and FT4.

Results: 33 patients have been included, mean age was 47 years (28-70), mean age at diagnosis of cancer was 42(25-64), 91%were women, type of cancer was 63.6% for papillary thyroid cancer and 27.3% of follicular variant of papillary thyroid cancer, 3% were follicular cancer and 6,1% were NIFTP. All patients underwent total thyroidectomy. Concerning TNM classification; 75.7% were T1 including 33.3% of T1a, 15% were T2 and 3% were T3. 15% were N1. According to the 8 AJCC staging system, 97% were stage 1 and 3% were stage 2. In accordance with the modified 2009 American Thyroid Association (ATA) risk stratification system 72.7% were at low risk, 21.2% at intermediate risk, and 6.1% at high risk. 60% of patients have received Radioiodine therapy. Concerning cardiometabolic risk factors, 36.4% had hypertension which was diagnosed after thyroid cancer surgery in 18.2%. 21.2% were diabetic or prediabetic with the diagnosis made after surgery in 6.2% of patients, dyslipidemia was diagnosed in 48.5% of patients and 78.8% of patients were overweight or obese. Just one patient was a current smoker.

Conclusion: In this cohort of Algerian thyroid cancer survivals, the risk of death by cancer is low in most cases, however, cardiometabolic risk factors are prevalent and more attention for cardiovascular prevention is needed for these patients.