ETA2022 Poster Presentations Thyroid Cancer CLINICAL 1 (10 abstracts)
Comparison between minimal and gross ete for risk of recurrence in papillary thyroid carcinoma : a propensity score matching study
Joonseon Park 1 , il ku kang 1 , Kwangsoon Kim 2 , Ja Seong Bae 3 & jeongsoo kim 1
1Department of Surgery , Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital Seoul, Republic of Korea; Seoul St. Mary’s Hospital; Surgery, Seoul, Rep. of South Korea; 2College of Medicine, the Catholic University of Korea, Department of Surgery , Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital Seoul, Republic of Korea; Seoul St. Mary’s Hospital; Surgery, Seoul, Rep. of South Korea; 3Department of Surgery , Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital Seoul, Republic of Korea, Seoul St. Mary’s Hospital, Surgery, Seoul, Korea, Rep. of South
Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for papillary thyroid microcarcinoma (PTMC) in subanalysis was done.
Methods: We assessed 4452 patients with DTC who underwent thyroid surgery from January 2009 to December 2015 at Seoul St. Mary’s Hospital (Seoul, Korea). Clinicopathological characteristics and long-term oncologic outcomes between mETE and gETE in PTC were compared using propensity score matching to reduce selection bias. The mean follow-up duration was 122.7 ± 22.5 months.
Results: There was no statistically significant difference in recurrence when comparing mETE group and gETE group before propensity score matcing (P = 0.072). In multivariate Cox regression analysis, mETE and gETE were not associated with an increased risk of recurrence After propensity score matching, there was no statistically significant difference in recurrence when comparing mETE group and gETE group (P = 0.668). Moreover, gETE did not show statistically significance compared with mETE in univariate and multivariate Cox regression analysis. Lymphatic invasion features and positive lymph nodes were shown as independent risk factors for tumor recurrence. Similar results were shown in PTMC subanalysis.
Conclusions: There was no statistically significant difference in tumor recurrence and DFS between the mETE and gETE groups after propensity score matching. The results of this study suggest that, like gETE, PTC patients with mETE should be carefully followed up because of equal risk of recurrence. Furthermore, we might reconsider the T staging system classification.
Keywords: Minimal ETE, Gross ETE, Papillary thyroid carcinoma, Recurrence risk, Propensity score matching
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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