ETA2022 Poster Presentations Pregnancy & Iodine (9 abstracts)
Higher thyroid FT3-to-FT4 ratio is associated with gestational diabetes mellitus and adverse pregnancy outcomes
Lore Raets 1 , Caro Minschart 1 , Annick Van Den Bruel 2 , Emmelien Van en Bogaert 3 , Paul Van Crombrugge 4 , Carolien Moyson 5 , Johan Verhaeghe 6 , Sofie Vandeginste 7 , Hilde Verlaenen 7 , Chris Vercammen 8 , Toon Maes 8 , Els Dufraimont 9 , Nele Roggen 9 , Christophe De Block 10 , Yves Jacquemyn 11 , Farah Mekahli 12 , Katrien De Clippel 13 , Anne Loccufier 13 , Annouschka Laenen 14 , Roland Devlieger 15 , Chantal Mathieu 16 , Brigitte Decallonne 17 & Katrien Benhalima 18
1Ku Leuven, Clinical & Experimental Endocrinology, Leuven, Belgium; 2Az St Jan Brugge, Department of Endocrinology, Brugge, Belgium; 3Ku Leuven, Medicine, Leuven, Belgium; 4Olvz Aalst-Asse-Ninove, Endocrinology, Belgium; 5Uz Leuven; 6Uz Leuven, Obstetrics & Gynecology; 7Olvz Aalst-Asse-Ninove, Obstetrics & Gynecology, Belgium; 8Imelda Bonheiden, Endocrinology, Belgium; 9Imelda Bonheiden, Obstetrics & Gynecology, Belgium; 10Uz Antwerpen, Endocrinology, Belgium; 11Uz Antwerpen, Obstetrics & Gynecology, Belgium; 12Kliniek St-Jan Brussel, Endocrinology, Belgium; 13Kliniek St-Jan Brussel, Obstetrics & Gynecology, Belgium; 14Ku Leuven, Center of Biostatics and Statistical Bioinformatics, Belgium; 15Uz Leuven, Obstetrics & Gynecology, Belgium; 16Uz Leuven, Leuven, Belgium; 17Ku Leuven, University Hospitals Leuven, Endocrinology, Leuven, Belgium; 18Uz Leuven, Endocrinology, Belgium
Aim: To determine the association between thyroid function and the risk for gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.
Methods: This case-control study was a sub-analysis of the BEDIP-N study, in which 199 GDM women were matched for age and body mass index with 398 controls. Thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and thyroid peroxidase (TPO) antibodies were measured at 6-14 weeks and 26-28 weeks pregnancy. TSH and fT4 were also measured in early postpartum in GDM women.
Results: TSH and TPO were not associated with the risk to develop GDM. The fT3-to-fT4 ratio at 26-28 weeks was positively associated with GDM risk with an adjusted odds ratio (aOR for smoking, education, parity, ethnicity, gestational weight gain and (family) history of diabetes or GDM) of 2.12 (95% CI 1.07; 4.23) comparing the highest with the lowest tertile. Higher fT3 levels and fT3-to-fT4 ratio were associated with a less favorable metabolic profile with higher BMI and more insulin resistance in pregnancy and postpartum. Women in the upper fT3 tertile and upper fT3-to-fT4 ratio had a higher rate of preeclampsia [respectively 4.6% (10) vs. 1.0% (2), P = 0.040, and 4.4% (9) vs. 0.5% (1), P = 0.020], gestational hypertension [8.3% (18) vs. 3.1% (6), P = 0.034 and 8.9% (18) vs. 2.0% (4), P = 0.003], and caesarean sections [29.4% (63) vs. 16.1% (31), P = 0.002 and 32.2% (65) vs. 12.7% (25), P < 0.001].
Conclusion: Higher fT3-to-fT4 ratio late in pregnancy was associated with GDM, adverse pregnancy outcomes, and an adverse metabolic profile in early postpartum.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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