Endocrine Abstracts

Objective: To study the life quality of patients with subclinical hypothyroidism by using questionnaire SF-36 before and after replacement therapy.

Methods: All patients were collected at the Department of Endocrinology 3rd clinics of Tashkent Medical Academy. The study included 55 women with subclinical hypothyroidism and 20 women for the control group. The age surveyed had an average of 37,6 ± 8,83 years. Patients included in the study do not take replacement therapy with thyroid hormones. All patients were divided into 2 groups: group 1 included 55 patients with subclinical hypothyroidism and the 2nd group of 30 women without thyroid disease. All patients had a test that assessed the quality of life with questionnaire SF-36 and ultrasound investigation of the thyroid gland (USI), conducted research analysis: thyroid hormone-binding free T4, TSH, and anti-thyroid peroxidase antibody.

Results: The first group of patients with subclinical hypothyroidism were obtained test results: TSH -6.9 free T4- 14,2, TPOAb - 87,6, thyroid gland volume V-24,8 cm³±7,8 and a second group members TSH -1.7 mU/l free T4-15,6 pmol/l and TPOAb -18,4. After replacement therapy in the first group, TSH and TPOAb levels were 1,9 mEd/l and 24,6 respectively. Average thyroid gland volume in the first and second groups was V-19,8 cm³ ±4,3 and V-14,6 cm³±3,6 respectively. The most common cause of subclinical hypothyroidism was Hashimoto’s thyroiditis with 83, 6%. In 26, 6% members of the second group were diffuse enlargement of the thyroid gland 1degree. Practically on all scales of the questionnaire SF-36, quality of life parameters in patients with compensated hypothyroidism was significantly lower, than in the group of healthy women. This study shows the relationship between increased rates of TSH and the deterioration of the quality of life in women with subclinical hypothyroidism.

Conclusion: In patients with subclinical hypothyroidism in almost all parameters the quality of life is worse than in women without thyroid disease, especially scales are worse, than in healthy women. While comparing the quality of life in patients with hypothyroidism the rates of role physical functioning, vitality, social functioning, and psychological health of patients with hypothyroidism were significantly less compared with women with euthyroid goiter.