EYES2022 ESE Young Endocrinologists and Scientists (EYES) 2022 Reproductive and Developmental Endocrinology (13 abstracts)
Which sperm parameter limits could really guide the clinical decision in assisted reproduction?
Dalla Valentina L. 1,2 , Spaggiari G 1 , Morini D 3 , Melli B. 3,4 , Aguzzoli L 3 , Villani M. T. 3 , Simoni M. 1,2 & Santi D. 1,2
1Azienda Ospedaliero-Universitaria of Modena, Department of Medical Specialties; 2 University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences; 3 Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Department of Obstetrics and Gynaecology; 4 University of Modena and Reggio Emilia, Clinical and Experimental Medicine PhD Program
Background: The predictive role of sperm motility and morphology was recently detected in a large sample of more than 20000 assisted reproductive technology (ART) fresh cycles. However, the complete ART procedure consisted in both fresh and frozen-embryos transfers and only a comprehensive evaluation of the entire process could really confirm if these parameters really predict the ART success.
Aim of the study: To identify predictive parameters of ART success, applying a real-world data analysis (RWD) on the entire ART path, combining fresh and frozen cycles.
Materials and Methods: A retrospective RWD analysis was performed, enrolling all couples attending a single ART centre from 2008 to 2021. The analysis included both fresh and frozen cycles, and both in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) procedures. Primary endpoints were strong ART outcomes, i.e. biochemical and clinical pregnancies and live birth rates (LBR).
Results: Fresh cycles success (considering LBR) was predicted by female age (OR: 1.04 [1.02-1.06]), injected oocytes (0.96 [0.93-0.99]), embryo number (0.79 [0.75-0.83]) and progressive sperm motility (0.98 [0.97-0.99]). On the contrary, frozen cycles outcomes were predicted only by sperm motility (0.97 [0.95-0.99]). This prediction was confirmed in IVF but not in ICSI cycles.
Conclusions: Both female and male’s parameters predicted the ART success considering entire path. However, frozen cycles success was predicted only by progressive sperm motility, suggesting that the potential amelioration of this male parameter is relevant to improve ART success. Those couples expected to obtain the highest embryos number after fertilization (low female age and better semen parameters) will have more attempts with frozen cycles and thus would benefit of a potential treatment focused to improve sperm parameters.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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