EYES2022 ESE Young Endocrinologists and Scientists (EYES) 2022 Reproductive and Developmental Endocrinology (13 abstracts)
Comparison of eunuchoid skeletal proportions in male hypogonadism between men with congenital hypogonadotropic hypogonadism (CHH) and Klinefelter Syndrome (KS)
Bellelli A. 1,2 , De Vincentis S. 1,2 , 3 , Corleto R. 1,2 , Zirilli L 1 , Santamaria E 1 , Granata A 2 & Rochira V. 1,2
1University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences; 2 Azienda Ospedaliero-Universitaria Policlinico di Modena (Italy), Unit of Endocrinology, Department of Medical Specialties; 3 University of Modena and Reggio Emilia, Clinical and Experimental Medicine PhD Program
Background: Patients with CHH and KS share eunuchoid body proportions of skeleton compared to normal male subjects. On the contrary, testosterone levels at puberty are lower in CHH patients compared to KS patients.
Aim: To compare anthropometric measurements of adult male CHH vs KS patients.
Methods: A prospective, cross-sectional, observational study was conducted. CHH patients were subdivided into 2 subgroups according to the timing of treatment start (testosterone replacement therapy [TRT] or gonadotropins): CHH1) CHH patients who started after 18 years; CHH2) CHH patients who started on time before 18. All KS patients started TRT after 18. Height, weight, sitting height, and arm span were collected by using a digital scale and stadiometer (Seca gmbh&co®); legs length, upper-to-lower segment ratio (U/l), upper-to-height, and upper-to-arm span were calculated.
Results: A total of 47 CHH1,23 CHH2 and 55 KS age-matched patients were enrolled (mean age 35.1±14.6, 31.0±11.2 and 36.4±13.5 years, respectively). CHH1 showed a longer arm span compared to CHH2 (P < 0.001) and KS (P = 0.004), and a shorter sitting height (P = 0.001) compared to KS. Furthermore, legs length was shorter in CHH2 compared to CHH1 (P < 0.001) and KS (P = 0.004). U/l and upper-to-height ratios were lower in CHH1 compared to CHH2 (P < 0.001) and KS (P < 0.001). On the contrary, the arm span-to-height ratio was higher in CHH1 compared to CHH2 (P = 0.004) and KS (P < 0.001).
Conclusions: Comparing adult CHH to KS patients, we observed more fine difference under the same definition of eunuchoid skeleton. CHH1 patients who delayed treatment showed longer arm length and lower U/l compared to CHH2 and KS. This suggests a different mechanism involved in eunuchoid skeleton development between CHH and KS confirming a major role for estrogen/androgen deficiency in the former and a possible role of genetic supernumerary X in the latter, displaying an early disproportional growth.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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