Endocrine Abstracts

Background: Exogenous follicle-stimulating hormone (FSH) administration in male idiopathic infertility showed the most convincing rationale in the face of a clinical efficacy below expectations. It was calculated that 10 to 18 men have to be treated to achieve one pregnancy.Objectives: To assess the effectiveness of FSH administration in male idiopathic infertility in a clinical setting.Methods: A retrospective real-world study was...

Background: It is widely demonstrated that obesity and hypogonadism are bi-directionally correlated, since the hypogonadism prevalence is higher in obese population, while weight loss increases testosterone serum levels. Several approaches are available to contrast weight excess, from simple dietary regimens to more complex surgical procedures. Ketogenic diets (KD) fit in this context and their application is growing year after year, aiming to improve the metabolic and weight ...

Background: The predictive role of sperm motility and morphology was recently detected in a large sample of more than 20000 assisted reproductive technology (ART) fresh cycles. However, the complete ART procedure consisted in both fresh and frozen-embryos transfers and only a comprehensive evaluation of the entire process could really confirm if these parameters really predict the ART success.Aim of the study: To identify predictive parameters of ART suc...

Background: Patients with CHH and KS share eunuchoid body proportions of skeleton compared to normal male subjects. On the contrary, testosterone levels at puberty are lower in CHH patients compared to KS patients.Aim: To compare anthropometric measurements of adult male CHH vs KS patients.Methods: A prospective, cross-sectional, observational study was conducted. CHH patients were subdivided into 2 subgroups according to the timin...

Background: Erectile dysfunction (ED) is the most frequent sexual disorder. Although psychological ED (pED) is the most frequent form, vascular ED (vED) is associated with 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients’ health, measured by the comorbidities number, in relation to the ED aetiology has never been investigated so far.Objectives: To explore the potential r...

Background: Thyroid autoantibodies cross blood-follicle barrier in titer dependent manner and may change oocyte microenvironment with adverse effects on implantation or post-implantation period. Thyroid autoimmunity (TAI) interfers with pregnancy course and newborn anthropometry in pregnancy achieved by assisted reproduction (ART).Objective: To light upon pregnancy course outcomes and newborn anthropometric characteristics regarding TAI in ART programme....

Introduction: Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumor.Case presentation: A 51-year-old lady presented with excessive hair on her face and lower abdomen of 1 year duration which affected her quality of life. Her menopause started 3 years ago. Her body mass index was 28.6 kg/m2. She had hair on her upper lip, chin, and lower abdomen; she had a Ferriman–Gall...

Background: Bone mineral density measurement sometimes reveals osteoporosis that is a consequence of undiagnosed or neglected long-standing health disorders. These secondary causes of osteoporosis should be carefully investigated, especially in men.Case Presentation: A 63-year-old male complained of back pain and was referred to endocrinology clinic due to a poor densitometry finding indicating osteoporosis. He presented with severe obesity (body mass in...

State of the art: In pharmacology, human chorionic gonadotropin (hCG) is considered equivalent to luteinising hormone (LH) since both act on the same receptor. Thus, when testicular function needs to be clinically restored (i.e. in case of hypogonadotropic hypogonadism [HH]), hCG is used instead of LH. However, growing evidences showed LH and hCG activate different molecular pathways and offer different outcomes in women undergoing assisted reproduction. The different action b...

Background: Several clinical features of chronic liver disease, such as sarcopenia, anaemia, low bone mass and gynecomastia are similar as manifestation of hypogonadism. Decreased testosterone levels are common in patients with severe liver disease and are associated with worse clinical outcomes and mortality.Case Presentation: A 33-year-old patient was admitted to the hospital due to severe alcoholic hepatitis. He was in poor general condition, icteric,...

Background: Menstrual cycle characteristics are essential indicators of a woman’s reproductive health. The reliability of auto-reported data assesment of menstrual cycle length has been questioned. Objectives: The aim was to evaluate the reliability of auto-reported data on menstrual cycle regularity. Methods: We created an anonymous survey about reproductive health and menstrual cycle characteristics and shared it with women ...

Background: It was shown that women with polycystic ovary syndrome (PCOS) are at an increased risk of COVID-19. However, it is not known whether COVID-19 has any effects on reproductive health of PCOS patients.Objectives: Aim of the study was to evaluate possible effects of COVID-19 on reproductive health in patients with PCOS.Methods: An anonymous survey about reproductive health was conducted in PCOS patients and healthy control ...

Background: Gonadal dysgenesis (GD) is a congenital disorder of sex development resulting in gonadal dysfunction caused by a variety of underlying genetic aberrations. Psychiatric morbidity is more common in women with GD in comparison to the general population but whether this is the result of a hormonal disbalance is unknown. However, psychotic symptoms due to abrupt changes in blood estrogen levels have been commonly reported. The aim is to report the first case of a psycho...