EYES2022 ESE Young Endocrinologists and Scientists (EYES) 2022 Environmental Endocrinology (4 abstracts)
Influence of mercury on thyroid hormone levels in the Serbian population – Benchmark dose approach
Maric D 1 , Javorac D 1 , Baralic K 1 , Antonijević B 1 , Djukic-Cosic D 1 , Bulat Z 1 , Mandić-Rajčević S 2 & Buha Djordjevic A 1
1 University of Belgrade - Faculty of Belgrade, Department of Toxicology "Akademik Danilo Soldatović"; 2 Faculty of Medicine, University of Belgrade, Institute of Social Medicine and School of Public Health and Health Management
Introduction: It is known that many metals can contribute to thyroid dysfunction. Mercury (Hg) has attracted the attention of researchers because it is widespread in the environment (food, air, soil). However, only several studies deal with the exposure to low doses of Hg, which may reflect the real exposure of the general population.
Aim: This study examined the relationship between measured concentrations of Hg in the blood and levels of free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in the serum of subjects representing the general population of Serbia.
Methods: In a human biomonitoring study conducted as part of the DecodExpo project, 425 blood samples were collected from subjects (207 men and 218 women) at the Clinical Center and the Clinical Hospital Center "Bežanijska kosa" in Belgrade. The Hg concentration was then determined by inductively coupled plasma mass spectrometry. Chemiluminescent immunoassay on a Cobas e411 analyzer was used to measure serum FT4 and TSH levels. The dose-response relationship was determined using the Benchmark dose (BMD) approach and the analysis was performed in PROAST software.
Results: The estimated BMD interval (BMDI) for TSH was broad in men, and 0.494-10.2 μg/l in women. The relatively narrow BMDI obtained for Hg-TSH levels in women indicates high certainty in estimates that a blood Hg concentration of 0.494 μg/l (BMDL) can increase the risk of TSH levels by 10%. The obtained BMDL for women was lower than the median value (3,444 μg/l). Further, for the levels of Hg and FT4, the dose dependence was determined using continuous data and the levels of FT4 hormone decreased with increasing levels of Hg, although the obtained BMDI was wide indicating the high variability of the obtained data.
Conclusion: The obtained results revealed possible effects of Hg environmental levels on thyroid function homeostasis.
Volume 83
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more