ECE2022 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (202 abstracts)
COVID-19 pneumonia patients with 25(OH)D levels lower than 12 ng/ml are at increased risk of death
Juraj Smaha 1 , Martin Kužma 2 , Kristína Brázdilová 2 , Samuel Nachtmann 2 , Martin Jankovský 2 , Katarína Pastírová 2 , Andrea Gažová 3 , Peter Jackuliak 2 , Zdenko Killinger 2 , Ján Kyseloviž 2 , Tomáš Koller 2 , Neil Binkley 4 & Juraj Payer 2
1Comenius University Faculty of Medicine, 5th Department of Internal Medicine University Hospital Bratislava, Bratislava, Slovakia; 1Comenius University Faculty of Medicine, 5th Department of Internal Medicine University Hospital Bratislava, Bratislava, Slovakia; 3Comenius University Faculty of Medicine, Institue of Pharmacology and Clinical Pharmacology, Bratislava, Slovakia; 4University of Wisconsin Medical Sciences Center, Department of Medicine Geriatrics Faculty, Madison, Wisconsin, United States
Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.
Methods: A cohort study of 357 COVID-19 patients was conducted. Subjects were monitored until discharge or in-hospital death. At admission, severity parameters (CRP, IL-6, Charlson Comorbidity Index etc.) were assessed. These parameters were compared regarding 25(OH)D levels threshold 12 ng/ml, where values below 12 ng/ml were considered absolute vitamin D deficiency.
Results: 25(OH)D levels at the time of admission were independently associated with mortality (P<0.05). Non-survivors (n=168) had lower 25(OH)D levels, SO2, higher age, CRP, viral load, and Charlson Comorbidity Index in comparison to survivors. Patients with serum 25(OH)D levels < 12 ng/ml had higher mortality (55% vs. 45 %), viral load (21.5 vs 23.1) and Charlson Comorbidity Index (5.3 vs 4.4) in comparison to those with serum 25(OH)D levels >12 ng/ml (P<0.05).
Conclusions: COVID-19 patients with serum 25(OH)D levels < 12 ng/ml have higher mortality. Among other factors, severe vitamin D deficiency likely leads to poor outcome.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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