ECE2022 Poster Presentations Thyroid (136 abstracts)
Association between thyroid autoimmunity and gestational diabetes mellitus in euthyroid women
Georgiana Sitoris 1 , Kris Poppe 1 , Flora Veltri 1 , Malika Ichiche 1 , Pierre Kleynen 1 , Jean-Philippe Praet 2 & Serge Rozenberg 3
1Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Endocrine Unit, Bruxelles, Belgium; 2 Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Departement of Internal Medicine, Bruxelles, Belgium; 3 Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Departement of Gynecology and Obstetrics, Bruxelles, Belgium
Objective: Pregnant women with autoimmune (subclinical) hypothyroidism have an increased risk of developing gestational diabetes mellitus (GDM). However, this association remains controversial in euthyroid women with thyroid autoimmunity (TAI). Therefore, the aim of the study was to determine the association between TAI and GDM in euthyroid women in a logistic regression analysis with adjustments for baseline/demographic parameters.
Methods: Cross-sectional study in 1447 euthyroid women who performed their entire clinical/biological work-up and oral glucose tolerance test (OGTT) in our center. At median 13 (11-17) weeks of gestation, TSH, free T4 and thyroid peroxidase antibodies (TPOAb) were measured, baseline characteristics recorded and an OGTT was performed between 24-28 weeks of pregnancy. Exclusion criteria were pre-pregnancy diabetes, assisted pregnancies, and women with (treated) thyroid dysfunction before or after screening. The diagnosis of GDM was based on 2013 WHO criteria.
Results: Two hundred eighty women were diagnosed with GDM (19.4%), 26.1% in women with TAI and 18.9% in women without TAI (P=0.096). TAI was associated with GDM (adjusted odds ratio (aOR) 1.69 (95% CI, 1.01-2.82); P=0.046). Maternal age >30 years, pre-pregnancy BMI ≥30 kg/m2 and another than Caucasian background were also associated with GDM; aOR 1.93 (95% CI, 1.46-2.56); P<0.001, 2.03 (95% CI, 1.46-2.81); P<0.001 and 1.46 (95% CI, 1.03-2.06);P=0.034, respectively.
Conclusions: In our cohort, the presence of TAI in euthyroid pregnant women was associated with gestational diabetes. In line with literature data, higher age and obesity were associated too. Future studies should focus on treatment options that might decrease the development of GDM in euthyroid women with TAI.
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Endocrine Abstracts
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