Endocrine Abstracts

Objective: Hyperprolactinemia might be related to weight gain, metabolic syndrome, and insulin resistance. The aim of this study was to evaluate that patients with hyperprolactinemia were higher prevalence of metabolic syndrome than civilian population.

Methods: From 1st Jan. 1998 to 17th Nov. 2017, 950 patients newly diagnosed hyperprolactinemia in Pusan National University Hospital, Pusan, South Korea, were selected to enroll in a study conducted on hyperprolactinemia and metabolic syndrome. We analyzed the metabolic components measured value within 3 months of the highest plasma prolactin value recorded. Information of waist circumference, serum triglyceride, serum HDL cholesterol, blood pressure, fasting plasma glucose, and medication for dyslipidemia or hypertension or diabetes mellitus were collected. Moreover, we also collected the measured value of BMI, LDL cholesterol, total cholesterol. We compare the metabolic component value of our hyperprolactinemia patients with KNHANES 2010-2015 data.

Results: In 20s~50s fasting blood glucose and in 20s and 30s LDL cholesterol of hyperprolactinemia patients were higher than Korean population, but there was no significance. In 20s total cholesterol (P=0.008) and in 30s systolic blood pressure (P=0.00) of hyperprolactinemia patients was significantly higher than Korean population. The prevalence of metabolic components were higher in patients with hyperprolactinemia than Korean population at triglyceride and blood pressure in 20s, 30s, but there was no significance. But, at fasting blood glucose in 20s, the prevalence of metabolic components were significantly higher in patients with hyperprolactinemia than Korean population (P=0.006). Incidence of obesity of patients with hyperprolactinemia was higher than Korean population over 30s, but there was no significance.

Conclusion: This study suggests the necessity of evaluation of metabolic syndrome for patients with hyperprolactinemia. In the future, larger epidemiological studies on prevalence of metabolic syndrome in patients with hyperprolactinemia should be performed.