ECE2022 Eposter Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Hormonal profile in idiopathic male infertility
Dinu Draganescu Daniela 1 , Anca Botezatu 2 , SUZANA VILMA VLADOIU 1 , Fudulu Alina 2 , Albulescu Adrian 2 , Oana-Monica Popa 1 , Andrei Muresan 1 , Plesa Adriana 2 , Iancu Iulia Virginia 2 , Dinu Draganescu Daria 3 , Cristina Stancu 1 , Velicu Alexandru 1 , Purice Mariana 1 , Padure Adriana 1 , Udrea Luminita 1 , Kremer Andreea 1 , Dumitrica Alina Elena 1 & Corin Badiu 1
1C.I. Parhon National Institute of Endocrinology, Bucureşti, Romania; 2Ştefan S. Nicolau Institute of Virology, Molecular virology, Bucharest, Romania; 3University Medical Center Groningen, Groningen, Netherlands
Male infertility arises as a global public health in the context of the dramatic decrease in birth rates, within a complex picture of hormonal, genetic and epigenetic factors. However, the underlying causes of male infertility remain unknown in many cases. Our study included samples (n = 82, median: 34 years, range 20–55 years) obtained from men investigating couple infertility and from a normal control group (n = 11, median: 29 years, range 21–55 years). Blood and seminal fluid were harvested after 3–5 days of sexual abstinence. Hormonal profile was evaluated, including FSH, LH, testosterone, estradiol, inhibin B and prolactin. Exclusion criteria: Radiotherapy and/or pelvic chemotherapy (over the last 6 months), known genetic aberrations, endocrine diseases, urogenital infections, bilateral orchiectomy, vasectomy and occupational exposure to harmful organophosphorus hydrocarbons, ionizing radiation, heavy metals. Inclusion criteria: spermatic parameters according to WHO 2010 Standards (Word Health Organization, 2010). The infertile group was divided in three subgroups: azoospermia (AZO n = 23), oligoasthenozoospermia/severe oligoasthenozoospermia (OAS/OASS n = 14), oligoasthenoteratozoospermia/severe, oligoasthenoteratozoospermia (OATS/OATSS n = 41). The analysis of hormonal profile displayed statistically significant differences for FSH (P=0.0003), LH (P=0.0092), prolactin (P=0.043), and inhibin B (0.0003). Moreover, a significant difference between azoospermia and control group was noted regarding FSH/E2 ratio (median: 0.4532 vs 0.152; P=0.00163). A similar pattern was displayed by the FSH/E2 ratio between subjects with <1 million spermatozoa/ml and control group (median: 0.420 vs 0.152; P=0.00174). The motility/E2 ratio was significantly lower in the azoospermia group compared to the control group (median: 0.000 vs 2.064; P=0.034). Sperm concentration/E2 ratio displayed a significant difference between the selected groups vs the control group (median: AZO-0; OAS/OASS-63328; OATS-70998; control-1453000). Investigating the LH/T and T/LH ratio, it was observed a significant difference between azoospermia and control group (median:2.207 vs 1.097, P=0.0094; respectively median:0.373 vs 0.912; P=0.0388). Subtle imbalances of reproductive hormones levels, revealed by disturbed evaluated ratios might be one of the causes of inappropriate sperm production mechanism. It appears that estrogen activity as reflected in the investigated ratios, is important with regards to proper fertility in males, since the spermatogenesis is modulated by estrogen at the level of HPG axis. In conclusion, investigated ratios could serve as a potential instrument in the diagnosis and management of male infertility, since these hormones cooperate to maintain the semen quality, stability and feedback control of the system.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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