Endocrine Abstracts

Backgrounds: Based on anthropometry and blood biochemical tests, this study aims to analyze the variation of glucose and lipid metabolism in Cushing’s syndrome (CS) patients caused by adrenal adenoma combining with flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA).

Methods: According to the strict diagnostic and exclusion criteria, seven healthy controls (HCs) and seven CS patients were collected in this study. First, the anthropometric parameters and blood biochemical indexes of all subjects were collected. Subsequently, their body composition of the whole body were measured by DEXA. Finally, all were equipped with a sensor of FGMS, and the blood glucose levels were recorded. According to the data of FGMS, the related indexes of blood glucose variation were calculated. The data between HCs and the CS group were analyzed by T-test or Mann–Whitney test.

Results: (1) Anthropometric parameters: compared with HCs, the CS group showed the higher waist circumference and waist-to-hip ratio (all P<0.005); (2) Blood biochemical indexes: the levels of HbA1c%, TG, TC and LDL-C in the CS group were higher than those in HCs (all P<0.005), while FBG and FINS were generally unaffected in the CS group than in HCs; (3) Data related FGMS: compared with HCs, the changes of general blood glucose alterations, within-day and day-to-day glucose variability, and the percentage of blood glucose above the standard range (PT3) were significantly higher, and the percentage of blood glucose within the standard range (PT2) was significantly lower (all P<0.005); (4) Data related DEXA: a significantly increased fat ratio in Android area (represent for midsection fat) was found in the CS group (all P<0.005), but no increase or decrease in fat or lean tissue of other areas were observed; (5) Fast insulin, HOMA-β index and HOMA-IR index of CS group tend to be higher than HCs, but there are no significant difference.

Conclusion: The homeostasis of glucolipid metabolism in the CS group was significantly destroyed, but impaired islet β-cell function and IR were not observed. A limitation of our study is its relatively small sample size due to the rare occurrence of CS.